Index Catalog // ScholarsArchive@OSU

Biosynthetic investigations of two secondary metabolites from the marine cyanobacterium Lyngbya majuscula

Creator:: Rossi, James V.
Abstract:: Marine cyanobacteria have been shown to produce a variety of biologically active and stucturally diverse secondary metabolites. These compounds are of interest to natural products researchers mainly because of their potential application as biomedicinals, biochemical probes, and agrichemicals. The metabolic pathways utilized by the cyanobacterium Lyngbya majuscula to generate curacin...
Resource Type:: Masters Thesis
Full Text:: from the marine cyanobacterium Lyngbya majuscula AN ABSTRACT OF THE THESIS OF James Rossi for the

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula

Creator:: Ramaswamy, Aishwarya V.
Abstract:: Cyanobacteria are rich in biologically active secondary metabolites, many of which have potential application as anticancer or antimicrobial drugs or as useful probes in cell biology studies. A Jamaican isolate of the marine cyanobacterium, Lyngbya majuscula was the source of a novel antifungal and cytotoxic secondary metabolite, hectochlorin. The structure...
Resource Type:: Dissertation
Full Text:: Biochemical Characterization of the Hectochiorin Biosynthetic Gene Cluster from the Marine Cyanobacterium

Natural products studies of the marine cyanobacterium Lyngbya majuscula

Creator:: Sitachitta, Namthip
Abstract:: The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...
Resource Type:: Dissertation
Full Text:: that of arenastatin A (14), a metabolite from the marine sponge Dysidea arenaria, another sponge

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Creator:: Marquez, Brian L.
Abstract:: This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...
Resource Type:: Dissertation
Full Text:: Doctor of Philosophy in Pharmacy presented jj 29, 2001. Title: Structure and Biosynthesis of Marine

Synthetic studies on indolic enamide natural products: 1. Total syntheses of coscinamide A, concinamide B and igzamide: 2. Synthetic studies towards the synthesis of halocyamine B

Creator:: Ma, Yuelong
Abstract:: The 3-substituded indolic enamide moiety has been found in many marine compounds over the past 20 years. These indolic enamides exhibit various biological properties such as cytotoxic, anthelmintic, antimicrobial and HW-inhibitory activities. Among these indolic enamides, some are (E)-enamides, like coscinamide A and coscinamide B, others are (Z)-configuration in their...
Resource Type:: Masters Thesis
Full Text:: The marine environment, covering 70% of the earth's surface and 95% of its tropical biosphere

Synthetic studies on marine natural products : Part 1. Synthesis of the sesquiterpenoid dihydropallescensin D via manganese(III)- mediated carbocyclization. Part 2. Approaches toward the synthesis of prianosin and discorhabdin alkaloids

Creator:: Yager, Kraig M.
Resource Type:: Dissertation
Full Text:: Synthetic studies on marine natural products : Part 1

Studies toward the synthesis of halichlorine and pinnaic acid

Creator:: Korf, Eric A.
Abstract:: Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
Resource Type:: Dissertation
Full Text:: INTRODUCTION Marine life continues to provide an abundance of novel metabolites which are of interest

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Creator:: Vulpanovici, Florina Alexandra
Abstract:: This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite, phormidolide,...
Resource Type:: Dissertation
Full Text:: five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite

Novel secondary metabolites from a Madagascar collection of Lyngbya majuscula

Creator:: Nannini, Christopher J.
Abstract:: Marine organisms produce a variety of secondary metabolites for defense, communication, and reproduction. While these uses are essential for the organisms' survival, marine natural products have demonstrated their value to human society as well. Asian countries used algae for centuries to treat or prevent illnesses as wide-ranging as cough, gout,...
Resource Type:: Masters Thesis
Full Text:: from a Madagascar Collection of Lyngbya ma/uscula. Abstract approved William H. Gerwick Marine

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: Metabolite Biosynthesis: I. Isolation of Natural Product Biosynthesis Gene Clusters from Symbiotic Marine

ScholarsArchive@OSU

Biosynthetic investigations of two secondary metabolites from the marine cyanobacterium Lyngbya majuscula

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula

Natural products studies of the marine cyanobacterium Lyngbya majuscula

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Synthetic studies on indolic enamide natural products: 1. Total syntheses of coscinamide A, concinamide B and igzamide: 2. Synthetic studies towards the synthesis of halocyamine B

Synthetic studies on marine natural products : Part 1. Synthesis of the sesquiterpenoid dihydropallescensin D via manganese(III)- mediated carbocyclization. Part 2. Approaches toward the synthesis of prianosin and discorhabdin alkaloids

Studies toward the synthesis of halichlorine and pinnaic acid

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Novel secondary metabolites from a Madagascar collection of Lyngbya majuscula

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

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