Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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, AlanE. Mark, John L. Markley, Matthew Miller, Wladek
Minor, Gaetano T. Montelione, Garib Murshudov
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
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Tobias Krojer,22 Joseph Marcotrigiano,6,23 AlanE. Mark,24 John L. Markley,25 Matthew
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Experiments were performed to determine the nature of
maize influence on bean disease in additive-type
intercrops. Overall effects of intercrops on angular leaf
spot (caused by Phaeoisariopsis griseola) in Kenya
indicated >23% reductions (P<0.05) in area under the
disease progress curve (AUDPC) in two of three season-site
combinations. Fertilization tended...
Conceptually, the dynamics of wood in streams can be viewed in terms of input and in-channel processes. Input processes are associated with both the riparian (tree fall, bank cutting, windthrow) and upslope forests (mass failures). In-channel processes include log breakage, movement, and decomposition. A mechanistic view of these processes is...
Several aspects affecting population trends and overwintering of Neoseiulus
fallacis (Garman) on peppermint were examined. Neoseiulus fallacis was the most
abundant phytoseiid predator mite found in peppermint surveys throughout the western U.S. Results of pesticide exclusion and cage studies showed that N. fallacis controlled Tetranychus urticae (Koch) on peppermint in...
Ambifunctional axially chiral 2,2',6,6'-tetrasubstituted biphenyls containing nucleophilic (or basic) functional groups juxtaposed with hydrogen-bond donors were synthesized and their properties studied. Applications for the prepared biaryls as potential organocatalysts for enantioselective carbon-carbon bond forming reactions were examined. Processes investigated included: aldol, Michael, nitroaldol (Henry), and Baylis-Hillman reactions.
The novel amidoamine...
We used a new model, STANDCARB, to examine effects of various treatments on carbon (C) pools in the Pacific Northwest forest sector. Simulation experiments, with five replicates of each treatment, were used to investigate the effects of initial conditions, tree establishment rates, rotation length, tree utilization level, and slash burning...
Vital rates and population connectivity are fundamental concepts in animal ecology and such information is critical for successful conservation planning. The Black-backed Woodpecker (Picoides arcticus) is a species of conservation concern because of its strong association with forests recently burned by high-severity wildfire. However, several recent studies have found that...