At the Costa Rica Dome (CRD), upwelling associated with cyclonic circulation and the presence of a shallow thermocline support a highly productive biological habitat, exploited by marine fauna at several trophic levels. During January 2008, a cruise to the CRD by the R/V Pacific Storm was conducted to relocate blue...
Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Graphene and its derivatives are two-dimensional hexagonal lattices that possess desirable physicochemical properties leading to an ever-expanding list of industrial and biomedical uses. Graphene oxides (GOs) are becoming a popular graphene alternative and while there have been human safety studies, investigations of developmental toxicity are lacking. The use of distinct...
Many research projects suffer from limited data causing poor statistical analysis or limited results. The movement to high throughput methods has been building for many years and cross many different disciplines. Lots of these methods start out using pathways that generate large amounts of data but have limited methods to...
Per- and polyfluoroalkyl substances (PFAS) are contaminants of concern because they do not readily degrade in the environment. Some in vivo studies report that PFAS alter neurological development and are carcinogenic. Perfluorohexanesulfonamide (FHxSA) and 6:2 fluorotelomer sulfonate (6:2 FTS) are two PFASs, which are often detected in drinking water sources....
All animals have developed the critical ability to detect, respond to, and detoxify a large array of environmental chemicals and stressors that can cause adverse health effects. Important examples of landmark contaminants around the world are polycyclic aromatic hydrocarbons (PAHs) and dioxins, both of which can act via the aryl...
Per- and polyfluoroalkyl substances (PFAS) are a broad class of anthropogenic chemicals characterized by highly stable carbon-fluorine (C-F) bonds. PFAS are widely used in industrial and consumer products for their surface-active and stain-resistant properties and are ubiquitously detected in environmental media, biota, and human biomatrices. Although some PFAS are known...
The field of toxicology is challenged with a vast number of environmental chemicals and mixtures to which humans and ecosystems are exposed with limited toxicity data available. Chemical hazard assessment traditionally utilizes mammalian models and can be both cost- and time-limiting and may pose ethical concerns. To rapidly tackle this...
Green-tree retention is being implemented on state and
federal lands in Oregon. Silvicultural prescriptions with
tree and snag retention are thought to mimic natural
disturbance patterns in the Pacific Northwest more closely
than traditional silvicultural practices, which reduce
structural complexity. The effects of green-tree retention
on native bird species in...
1,10-phenanthroline and its non-chelating isomer, 1,7-phenanthroline were used to inhibit the replication of vaccinia virus (VV). Serial passage of VV in the presence of various concentrations of either 1,10-phenanthroline or 1,7-phenanthroline was carried out. No drug resistant mutants were isolated, suggesting that the observed inhibition was due to a cellular...
