When vessel walls within the vasculature are damaged, exposed extracellular
matrix (ECM) proteins trigger a series of events that lead to the formation of a
hemostatic plug (Andrews et al. 2004, Furie et al. 2008, Watson 2009). Thrombus
formation requires an orchestrated series of receptor-mediated events facilitating platelet
recruitment, platelet...
Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...
Tyrosine kinases mediate response of blood cells to stimuli and small molecule tyrosine kinase inhibitors (TKIs) serve important roles as drugs in managing hematological diseases. In healthy B cells, the B cell receptor (BCR) activates a tyrosine kinase known as Syk, which then activates BTK, PI3K, PLC2 and protein kinase...
The objective of this research was to indirectly determine the
existence of a possible retinal-endocrine pathway activated, or
Inhibited, by artificial fluorescent light as evidenced by it subsequent
effects on bone metabolism. Forty-eight male Long-Evans post-breeder
rats, half of which were bilaterally orbitally enucleated, were
used in this experiment. A...
The problem of synchronization arises in the interaction among
digital systems not sharing a common clock reference. The reliability of synchronizers is related to metastable operation of
bistable elements. Because of its subtle nature, the phenomenon
until recently was not widely researched. However, the literature
now contains a sound theoretical...
The relationship between a country's degree of openness and its economic well-being has been examined extensively both theoretically and empirically. Numerous empirical studies using different openness measures have found a positive effect of openness on growth. However, the validity of such measures have
come into question due to data issues....
Students with disabilities are not being afforded the same access to sporting opportunities as their peers without disabilities. The purpose of this dissertation was to build on a foundation of information regarding collegiate adaptive sports through a Critical Disabilities Studies lens. Specific aims included: (1) identifying and describing intercollegiate, adaptive...
The North Atlantic zone of Costa Rica is an alluvial plain, whose fairly good soils and warm, extremely wet climate generate serious weed problems in cultivated crops and pastureland. Basic foods - corn, beans, rice and yuca - are important small farm crops. New land is still being opened for...