DNA mismatch repair (MMR) is an evolutionarily conserved process used by cells to decrease mutation rates, thereby increasing genetic stability and reducing cancer risk. Germline mutations in the MMR gene MLH1 have been identified in Lynch Syndrome patients, and in many cases are suspected but not confirmed as causative for...
Previous attempts to understand the factors affecting the energetic cost of locomotion have found a direct link between the energetic cost and the mechanical work done during periods when the limb is in contact with the ground. However, when the limb is not in contact with the ground during the...
In the majority of management scenarios, it is imperative that beef replacement heifers calve at two years of age. In order to achieve this goal, yearling heifers should reach 60 to 65% of their mature body weight by 13 months of age. Feed costs represent 75 to 80% of the...
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James R. Males
In the majority of management scenarios, it is imperative that beef
Oxytocin is a hormone well know for the stimulation of childbirth and milk letdown in mammals. Large levels of the hormone are also released during angiogenesis in the growth of the corpus luteum (CL), a temporary endocrine gland that forms on the ovaries following ovulation. Levels of oxytocin decline after...
The objectives of this study were to determine the effects of acupuncture in dairy cows on caruncular matrix metalloproteinase type-2 (MMP2) tissue concentration and enzyme activity at 0, 2, and 4 hours after calving. Immediately after natural calving, a caruncle was obtained from the body of the uterus and flash...
Abstract
Haptoglobin is an acute phase protein that is elevated in response to tissue damage and infections in dairy cows. The objectives of this study were to evaluate whether serum haptoglobin concentrations in the first week after calving can indicate disease status and severity, and whether haptoglobin concentrations are elevated...
Inflammation is the body's response to injury and is characterized by pain, swelling, redness, and heat. Eicosanoids are lipid mediators of inflammation. Leukotrienes (LT) are 20-carbon eicosanoids produced from arachidonic acid (AA), an n-6 fatty acid (FA), and eicosapentaenoic acid (EPA), an n-3 FA. LT produced from AA are proinflammatory...
Prenatal exposure to excess androgens, testosterone in particular, has clear effects on potential ram fertility. Utilizing breeding soundness examinations in male sheep will assess the ram's potential ability to impregnate a certain number of healthy females during a defined breeding season. Identifying rams that have high breeding potential can provide...
Acute phase protein (APP) measurement can be used to characterize and rapidly detect inflammation. Serum amyloid A (SAA) and haptoglobin (HP) may be useful for diagnostic and prognostic purposes in horses presenting for colic and other inflammatory diseases. The objective of this thesis was to evaluate the use of SAA...