Two specific goals were addressed for this dissertation. First to investigate
and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity
by utilizing in vivo and in vitro approaches determining the mechanism of action
for the hepatotoxicity incurred. To date, there has not been a mechanistic
determination of the hepatotoxicity associated...
Reports of previous research indicated a stimulatory effect of
triazine herbicides on growth, yield and protein content of plants and
seeds of various species.
Studies were conducted in the greenhouse, laboratory and field
to investigate the effects of atrazine (2-chloro-4-ethylamino-6-a sopropylarnino-
s-triazine) on growth, yield, seed composition, and
In an experimental field study, populations of gray-tailed voles
(Microtus canicaudus) were exposed to a commercial formulation of
vinclozolin, a fungicide effective for disease control on ornamental plants,
turf grasses, and fruits and vegetables. Vinclozolin has been shown in
laboratory experiments to behave as an androgen antagonist, impairing
The aim of this study was to assess sensitivity of early life stage zebrafish to cadmium (Cd). Embryos and larva were exposed to Cd before the formation of skeletal elements. Exposure times were selected to determine whether Cd perturbed developmental processes that lead to skeletal deformities, and to characterize the...
Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...