DNA damage, if not repaired, can become a mutation. Mutation
accumulation is associated with initiation and progression of tumorigenesis. DNA
mismatch repair (MMR) is required for maintaining genetic stability by repairing
replication errors. Biochemical studies have shown that MMR also recognizes
mismatch-causing DNA lesions, suggesting the role of MMR in...
The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Nearly 9,000 feet of Cretaceous mudstones, shales, sandstone,
and conglomerates are exposed along the northeast-trending Mitchell
anticline of central Oregon, These rocks are divided into two formations
on the basis of criteria developed in this investigation. The
lower formation, hereby designated the Meyers Formation, is 4,716
feet thick at its...
In these tests, phenolic constituents from bark of Shasta red fir were found ineffective as stiffening agents for corrugating medium. Other means of application, however, may be effective.
Gum from inner bark of Shasta red fir was not so effective as a beater additive as was locust bean gum, but...