Index Catalog // ScholarsArchive@OSU

Creator:: Yueh, Mei-Fei
Abstract:: Flavin-containing monooxygenase (FMO, EC1.14.13.8) comprises a family of xenobiotic-metabolizing enzymes that catalyze the oxygenation of a wide variety of xenobiotics, most commonly nitrogen and sulfur. Mammals express five different FMOs in a species- and tissue- specific manner. FMO2, is expressed predominantly in lung and differs from other FMOs in that...
Resource Type:: Dissertation
Full Text:: monooxygenase system, the properties of FMO and its contribution to drug metabolism, in terms of

Creator:: Hamamura, Natsuko
Resource Type:: Masters Thesis
Full Text:: bacteria. These results suggest that butane monooxygenase is responsible for CF degradation. The addition

Creator:: Storfa, Ryan T.
Abstract:: Butane-grown cells of Pseudomonas butanovora, Nocardioides sp. CF8 and Mycobacterium vaccae JOB5 were tested for their ability to cooxidize methane, ammonia and ethylene. Less than 10 nmol of methane were degraded by each of the bacteria (0.17-0.35 mg protein) in 30 minutes. Hydroxylamine and nitrite accumulated when Nocardioides CF8 and...
Resource Type:: Masters Thesis
Full Text:: inactivation of butane monooxygenase AN ABSTRACT OF THE THESIS OF Ryan T. Storfa for the degree of Master

Creator:: Driggers, Camden McCullough
Abstract:: Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
Resource Type:: Dissertation
Full Text:: NADPH-dependent FMN- reductase, SsuE, and a monooxygenase, SsuD. Once cysteine (Cys) is available to a

Creator:: Doughty, David M.
Abstract:: The regulation of monooxygenase enzymes has been demonstrated in bacteria that grow on methane and long chain-length alkanes (>C10). Less is known about monooxygenase regulation in short chain alkane oxidizing bacteria that grow on intermediate chain-length alkanes C2-C10. This dissertation focuses on the regulation of butane monooxygenase (BMO) expression and...
Resource Type:: Dissertation
Full Text:: alkane metabolism is initiated by a monooxygenase in P. butanovora, alkane-dependent growth only

Creator:: Singh, Priti B.
Abstract:: Multiple drug resistance (MDR) Tuberculosis (TB), leads to increased use of “second-line” drugs; one of the most effective is ethionamide (ETA). ETA is a prodrug metabolized by a mycobacterial flavin-containing monooxygenase (EtaA) as well human flavin-containing monooxygenases (FMOs). Of the five functional FMOs of humans, FMOs 1, 2, and 3...
Resource Type:: Masters Thesis
Full Text:: Flavin- Containing Monooxygenase: Metabolism and Toxicity

Creator:: Skinner, Kristin M.
Abstract:: Graphium sp., a eukaryotic alkanotroph, is able to oxidize small-molecular weight gaseous n-alkanes, diethyl ether and the branched ether, methyl tert butyl ether (MTBE). However, information regarding the biochemistry of fungal-mediated alkane and ether metabolism is limited, and questions regarding the identity of alkane oxidation catalysts and the genetic underpinnings...
Resource Type:: Dissertation
Full Text:: ether metabolism is limited, and questions regarding the identity of alkane oxidation catalysts and

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