Mathematical modeling plays a pivotal role in understanding the mechanism of radiation-induced cellular effects, and also in quantifying the radiation risk to the cell. However, there are still compelling challenges facing the conventional modeling in radiobiology, such as lacking a generalized theory structure of quantifying target effect and non-target effect...
Distinct aggregations of fungal hyphae and rhizomorphs, or "mats", formed by some genera of ectomycorrhizal (EcM) fungi are common features of soils in coniferous forests of the Pacific Northwest. We measured in situ respiration rates of Piloderma mats and neighboring non-mat soils in an old-growth Douglas-fir forest in western Oregon...
The objective of this research is to support DfX considerations in the early phases of design, particularly Design for the Environment. In order to include DfX considerations, especially early in the design process, there needs to be access to knowledge and information that is usually only applicable further downstream in...
Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
This paper addresses the high model complexity and overconfident frame labeling of state-of-the-art (SOTA) action segmenters. Their complexity is typically justified by the need to sequentially refine action segmentation through multiple stages of a deep architecture. However, this multistage refinement does not take into account uncertainty of frame labeling predicted...
Soil respiration, or the combined CO₂ emissions from roots and soil microorganisms, constitutes one of the largest losses of carbon (C) from terrestrial ecosystems. The major drivers of soil respiration, which include soil moisture, temperature, and substrate quality, have been known for some time. Nevertheless,
correlations between these drivers and...
Gene regulation is a complex mechanism that controls the spatial and temporal expression of genes in a living cell. My dissertation studies focus on two problems. First, tissue-specific gene expression prediction from DNA sequence and chromatin state, and second, the accurate discovery of small over-represented regulatory circuits in gene regulatory...
Animals aggregate and interact in nonuniform and nonrandom patterns, which lead to group level characteristics that have important evolutionary and ecological consequences. Network analysis provides a useful conceptual framework for linking animal interactions at all scales from dyads to communities, to populations and ecosystems. Despite exciting theoretical and applied advances...
Archaeological investigations at the Cooper's Ferry site in Western Idaho have recovered cultural remains dating to 16,000 years ago, suggesting the oldest human occupation recorded in North America. However, many archaeologists have argued the initial peopling of North America occurred no earlier than the opening of an ice-free corridor between...