Replication associated protein and enzyme activity levels increase as cells enter
S-phase of the cell cycle and diminish as cells leave S-phase. Accordingly, replication
associated functions decrease as myoblasts withdraw from the cell cycle to terminally
differentiate. In an effort to understand signals effecting growth associated expression
of genes, the...
Cells of the ventrolateral dermomyotome delaminate and migrate into the limb buds where they give rise to all muscles of the limbs. The migratory cells proliferate and form myoblasts, which withdraw from the cell cycle to become terminally differentiated myocytes. The regulatory mechanisms that control the later steps of this...
The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
Homeodomain transcription factors control developmental processes. They pattern body formation, specify cell lineages and switch the onset of gene regulatory cascades. Pitx2, a bicoid-related homeodomain transcription factor, is asymmetrically expressed in the left lateral plate mesoderm and mesoderm-derived tissues. Pitx2 null mice are characterized by failure of body wall closure,...
Organismal development requires a precisely orchestrated transcriptional program to correctly deploy genetic information into the genome. This process requires sophisticated gene regulatory networks at multiple spatial and temporal levels from early embryonic development to adult physiological conditions. Molecular differences that define cell types are set up during the pattern formation...
Congenital myopathies are caused by heritable mutations in particular genes. Genes mutated in congenital muscular dystrophies often encode cytoskeletal proteins, which contribute to the shape and movement of cells. We would like to know how such molecular defects lead to the muscle weakness in patients. It is therefore important to...