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Preparing sustained release dosage forms of nifedipine by hot-melt coating method

Creator:: Le, Hang Thi
Abstract:: A nifedipine sustained release dosage form was prepared by using hot-melt batch coating. Substrates are sugar beads, mesh size 30-35. Stearic acid, Acid Triglyceride, and carnauba wax were coating agents used to make single layer coated beads and multiple layer coated beads containing nifedipine. Dissolution of nifedipine from the beads...
Resource Type:: Masters Thesis
Full Text:: ........................................... I Controlled drug release dosage forms, sustained drug release dosage forms

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

Creator:: Fahmy, Sahar Abd El-Sattar
Abstract:: This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was...
Resource Type:: Dissertation
Full Text:: conducted and showed that controlled release of nifedipine was obtained by increasing the ratio of the

New product formulations and pharmacokinetics of acetaminophen

Creator:: Borin, Marie T.
Resource Type:: Dissertation
Full Text:: tablet poses quite a challenge since all known controlled or sustained release systems for oral

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation
Full Text:: linearity of kinetics. Acetaminophen is a prime candidate for sustained release dosage forms (chapter II

Formulation of an oral acetylsalicylic acid suspension and pharmacokinetics of parenteral thrombomodulin analogues

Creator:: Piepmeier, Edward H.
Abstract:: Sustained concentrations of active compound were maintained in vitro and in vivo for an oral and a parenteral dosage form respectively. The vehicle of a oral dosage form was modified and the molecular structure of a parenteral dosage form was modified. An oral dosage form was tested in vitro using...
Resource Type:: Dissertation
Full Text:: acid was compared to two controlled release forms and two immediate release dosage forms which are

Development of Hot-melt Pan-coating, Application to Sustained-release Capsules and Tamper Resistant-coating. 2) Formulation of Verapamil HCl and Diltiazem HCl Semisolid Matrix Capsules. 3) Novel Sustained Release Tablet of Glipizide: Compression of Coated Drug Beads, Formulation, Dissolution, and Convolution. 4) Verapamil Sustained Release: New Formulation and Convolution

Creator:: Nguyen, Chien Ngoc
Abstract:: Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
Resource Type:: Dissertation
Full Text:: . Drug loaded beads were subsequently spray-coated with a hardening layer, then a controlled release

New acetaminophen products : formulation development and bioavailability

Creator:: Mansell, Libbie J.
Abstract:: Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
Resource Type:: Dissertation
Full Text:: dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Creator:: Hossain, Mohammad
Abstract:: Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate...
Resource Type:: Dissertation
Full Text:: , non-erodible oral release dosage forms. Development of controlled release dosage forms where the

Development and evaluation of a sustained release amoxicillin dosage form

Creator:: Ge, Yan, 1962-
Resource Type:: Masters Thesis
Full Text:: formulation were not provided. The controlled release formulation had rather low bioavailability in

Pharmacokinetics and pharmacodynamics of: 1) Oral sustained release acetaminophen suspension in children; 2) Potassium chloride in adults

Creator:: Kalns, John Eric
Resource Type:: Dissertation
Full Text:: of unpalatable drugs, 5) Release rate may be controlled by varying the amount of rate controlling

ScholarsArchive@OSU

Preparing sustained release dosage forms of nifedipine by hot-melt coating method

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

New product formulations and pharmacokinetics of acetaminophen

New product formulation and multiple dose pharmacokinetics of acetaminophen

Formulation of an oral acetylsalicylic acid suspension and pharmacokinetics of parenteral thrombomodulin analogues

New acetaminophen products : formulation development and bioavailability

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Development and evaluation of a sustained release amoxicillin dosage form

Pharmacokinetics and pharmacodynamics of: 1) Oral sustained release acetaminophen suspension in children; 2) Potassium chloride in adults

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