Index Catalog // ScholarsArchive@OSU

Creator:: Yang, Liping
Abstract:: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
Resource Type:: Dissertation
Full Text:: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription

Creator:: Trindade da Rosa, Fernanda
Abstract:: Mastitis is a major endemic disease in dairy cows resulting in significant economic losses for the dairy industry. The peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that is able to bind and be activated by natural (e.g., fatty acids) and synthetic (e.g. thiazolidinedione) compounds. PPARγ plays important roles...
Resource Type:: Masters Thesis
Full Text:: industry. The peroxisome proliferator-activated receptor gamma (PPAR) is a nuclear receptor that is able

Creator:: Jacobs, Dakota
Abstract:: Ovulation requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from preoptic hypothalamic neurons, initiated by elevated ovarian estradiol (E₂). Rising estradiol activates a subset of sexually dimorphic kisspeptin (Kiss-1) neurons in the female, located in the anteroventral periventricular nuclei (AVPV). Conversely, estradiol negative feedback on GnRH secretion is mediated by a...
Resource Type:: Masters Thesis
Full Text:: activity in the presence of estradiol. Further, we have found that expression alterations between nuclear

Creator:: Smith, Sarah M.
Abstract:: Metabolic improvements and changes in gene expression were measured in mice fed polyphenol-rich extracts derived from apples and sweet cherries, and the common phytochemicals, quercetin and ellagic acid. Polyphenol-rich extracts were produced by solid phase extraction and column chromatography. Extracts and purified compounds were mixed into a high-fat (HF, 60%...
Resource Type:: Masters Thesis
Full Text:: apples, cherries, and other fruits 32 Figure 1.3. General nuclear hormone receptor structure

Creator:: Clark, Sarah A.
Abstract:: Hub proteins bind a large number of partners to facilitate structural changes and downstream protein interactions. LC8, a highly conserved protein homodimer, is a unique hub that regulates the activity of proteins in a wide range of cellular processes by binding to intrinsically disordered regions. With many of these systems,...
Resource Type:: Dissertation
Full Text:: Biochemistry and Biophysics Department for welcoming me wholeheartedly even though I’m a Molecular and

ScholarsArchive@OSU