Methylthioadenosine (MTA) is a naturally occuring nucleoside formed during
the synthesis of polyamines in mammalian cells. MTA is rapidly catabolised
by MTA phosphorylase (MTAase), eventually yielding methionine and
adenine. MTAase has been shown to be active in all normal cells, but
deficient in some cells and tissues of malignant origin....
Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or...