As part of the International Polar Year research program, we conducted a survey of surface marine sediments from box cores along a section extending from the Bering Sea to Davis Strait via the Canadian Archipelago. We used bulk elemental and isotopic compositions, together with biomarkers and principal components analysis, to...
The frequent misidentification of Asian garments in small museum collections indicated the need for a garment identification system specifically for use in differentiating the various forms of Asian clothing. The decision tree system proposed in this thesis is intended to provide an instrument to distinguish the clothing styles of Japan,...
We document the age and extent of late Quaternary glaciofluvial processes in Garwood Valley, McMurdo Dry Valleys, Antarctica, using mapping, stratigraphy, geochronology, and geochemical analysis of sedimentary and ice deposits. Geomorphic and stratigraphic evidence indicates damming of the valley at its Ross Sea outlet by the expanded Ross Sea ice...
At Oregon State University a library collection assessment is a required part of the review process for every new academic program proposal. Over time, this assessment has moved away from a brief statement regarding the adequacy of the collection to support the new program to a more thorough evaluation and...
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:
Information Section 1.
1. Given Name (First Name)
AlisonE.
2. Surname (Last Name)
Heald
4. Are you the
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:
Nonhuman Primates and Humans
AlisonE. Heald, M.D., Jay S. Charleston, Ph.D., Patrick L. Iversen, Ph.D
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:
for Marburg Virus in Nonhuman
Primates and Humans
AlisonE. Heald, M.D., Jay S. Charleston, Ph.D
Studies reporting on potentially toxic interactions between aqueous fullerene nanoparticles (nC₆₀) and
microorganisms have been contradictory. When known confounding factors were avoided, growth yields of
Saccharomyces cerevisiae and Escherichia coli cultured in the presence and absence of independently prepared
lots of underivatized nC₆₀ were found not to be significantly different.