Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
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Biosynthesis
AndrewOsborn
Research Mentors: Dr. Taifo Mahmud, Dr. Kerry McPhail
A Bioresource
Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
Full Text:
By
AndrewOsborn
An Undergraduate Thesis Submitted to
Oregon State University
Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
Despite more than two centuries of exploration, including more than six million deep wellbores with depths exceeding 40,000 feet in some parts of the world, our ability to constrain subsurface processes and properties remains limited. Characteristics of the subsurface vary and can be analyzed on a variety of spatial scales....
A major challenge to the study of the peopling of the Americas is that much of the Bering Land Bridge (Beringia), the geographic area that people migrating from Northeast Asia into North America would presumably have passed through, is now submerged due to sea-level rise since the last glacial maximum....
Oregon's land use planning system is often recognized as having been successful in its goals of limiting urban sprawl and protecting resource lands from development. However, it is difficult to quantify the impact of these regulations, because we cannot observe what would have happened in the absence of land use...
Air temperatures at i m and soil temperatures at 2C cm are reported for
twenty-one forest stands in the central Western Cascader of Oregon. Records
began in 1970 for some stands, in 1971 or 1972 for most. Temperature Growth
Index for a stand, based on temperature effects on Douglas-fir seedling...
Stem mapping of all trees greater than 15 cm dbh has
been completed on the 10.24 hectare watershed (No. 10) at H. J.
Andrews intensive study site. Using a 25 m grid system, mapping
of vegetation into 7 plant communities and then into 4 habitat
types has also been completed....