This work entails both imaging and therapeutic applications of biomedical optics. In both contexts, an understanding of light transport in tissues is necessary. An overview of optical transport in tissues is given, including scattering theory. Digital Fourier holographic microscopy is introduced and applied as a means of metrology via optical...
The serotonergic system plays a significant regulatory role in osteoblast differentiation and proliferation. Serotonin (five-hydroxytryptamine or 5HT) may promote or inhibit osteoblast proliferation depending upon the serotonin receptor isoforms expressed by the cell. Classically, 5HT receptor 1B (5HTR1B) reduces osteoblast proliferation by inhibiting phosphorylation of the cAMP response element binding...
Signal transduction within and between cells is at the core of biological activity in all living systems. Signaling networks are required for regulating biological functions, including growth, development and survival. Deregulation of signaling cascades has been linked to chronic and acute diseases and disorders This thesis focuses on mass spectrometry...