A large number of experiments were done to detect and identify
one or more intermediates involved in coupling ATP synthesis to
electron transport. Using mitochondria from blowflies, addition of
ADP after a period of incubation with Pi³² was found to give rise to a
temporarily rapid esterification (the "ATP jump"),...
An investigation was conducted to ascertain if certain concepts
of microbial metabolism, derived from studies using simple
soluble substrates, are applicable to the biological assimilation of
complex, partially colloidal suspensions. A mixture containing one
gram of Carnation dry-skim milk is considered to be a complex,
partially colloidal substrate and was...
A study to determine the effect of certain synthetic organic
insecticides on the Biochemical Oxygen Demand (BOD) Test was
performed. BOD tests on a standard glucose-glutamic acid substrate
were conducted while in the presence of dieldrin, dichlorodiphenyltrichloroethane
(DDT), or diazinon. From the BOD data, the following
parameters were obtained:
1....
A two-part study was conducted with three poorly water soluble
drugs (phenylbutazone, tolbutamide, theophylline) to develop two new
drug delivery systems based on physical-chemical approaches.
In the first part, tolbutamide and phenylbutazone were made into
solid dispersions with various excipients using a lyophilization
technique. In vitro dissolution studies of these...
