Characterization and biological roles of the peroxisome proliferator-activated receptor (PPAR) isotypes are well known in monogastrics, but not in ruminants. However, a wealth of information has accumulated in little more than a decade on ruminant PPARs including isotype tissue distribution, response to synthetic and natural agonists, gene targets, and factors...
Peroxisome proliferator-activated receptors (PPARs) are members of a
large group of ligand-regulated transcription factors that includes nuclear
receptors for steroid and thyroid hormones, retinoids and vitamin D₃.
Synthetic fibrates and thiazolidinediones that bind to and activate PPARs are
used efficaciously in humans to remedy hypertriglyceridemia and non-insulin
dependent diabetes mellitus,...
The hypothesis of the study was that inhibition of PPAR/ increases glucose uptake and lactose synthesis in bovine mammary epithelial cells by reducing the expression of the glucose transporter mRNA destabiliser calreticulin. Three experiments were conducted to test the hypothesis using immortalised bovine mammary alveolar (MACT) and primary bovine mammary...
Nutrigenomics is a branch of nutrition that seeks to elucidate the relationship between dietary components and expression of genes. Certain bioactive compounds present in the diet have the potential to modulate transcription of genes through their interactions with ligand-dependent nuclear receptors, a series of transcriptional regulators capable of sensing intracellular...
Watermelon (Citrullus lanatus) is rich in lycopene and citrulline and has high phenolic content and antioxidant capacity. Previous studies demonstrate the health benefits of watermelon intake on improved blood pressure regulation along with others. Similarly, cherries, raspberries, walnuts and green tea are rich in anthocyanins, polyphenols, and polyunsaturated fatty acids...
Flavonoids are a large family of compounds synthesized by plants that have a common chemical structure. It is believed that the health effects of fruits and vegetables are primarily due to dietary flavonoids content. Current research indicates that dietary flavonoids show promise for mitigating and/or preventing chronic conditions associated with...
Background: The immune response to microbial infections is compromised in beef cattle at parturition. Innate and adaptive immunoglobulin M (IgM) serve as initial antibodies during microbial infection before the generation of adaptive immunoglobulin G (IgG). Selenium (Se) is an essential micronutrient required by all mammals, which can improve immune responses...
Nonalcoholic fatty liver disease is a major public health concern in the obese and type 2 diabetic populations. The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5). Elovl5 plays a key role in MUFA and PUFA...
Nonalcoholic fatty liver disease is a major public health concern in the obese and type 2 diabetic populations. The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5). Elovl5 plays a key role in MUFA and PUFA...
Full Text:
catabolism in obese C57BL/6J mice. Journal of Lipid Research, 55(7),
1448-1464. doi:10.1194/jlr.M050062