When vessel walls within the vasculature are damaged, exposed extracellular
matrix (ECM) proteins trigger a series of events that lead to the formation of a
hemostatic plug (Andrews et al. 2004, Furie et al. 2008, Watson 2009). Thrombus
formation requires an orchestrated series of receptor-mediated events facilitating platelet
recruitment, platelet...
Occlusive thrombi that cause cardiovascular diseases form on the walls of blood vessels and propagate across the lumen under pressure gradient-driven flow, impaired antithrombotic, and enhanced prothrombotic conditions. Development of a well controlled and validated ex vivo model that can mimic these pathological conditions would provide a useful tool for...
Full Text:
Model of Thrombosis
IshanA. Patel1, Michelle A. Berny-Lang1, Garth W. Tormoen1, Tara C. White-Adams1
Occlusive thrombi that cause cardiovascular diseases form on the walls of blood vessels and propagate across the lumen under pressure gradient-driven flow, impaired antithrombotic, and enhanced prothrombotic conditions. Development of a well controlled and validated ex vivo model that can mimic these pathological conditions would provide a useful tool for...
Full Text:
Thrombosis
IshanA. Patel1, Michelle A. Berny-Lang1, Garth W. Tormoen1, Tara C. White-Adams1, Erik I
Occlusive thrombi that cause cardiovascular diseases form on the walls of blood vessels and propagate across the lumen under pressure gradient-driven flow, impaired antithrombotic, and enhanced prothrombotic conditions. Development of a well controlled and validated ex vivo model that can mimic these pathological conditions would provide a useful tool for...
Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
Cystic fibrosis is an inherited genetic disease caused by a single gene mutation in the CFTR protein. Affecting 70,000 people worldwide, this disease is debilitating to patients, resulting in persistent lung infections and decreased quality of life. Due to the various mutation types, there is not currently a single drug...
Mathematics outreach typically consists of community events that show the exciting applications of mathematics, particularly to K-12 students. The goal of mathematics outreach events is to increase student interest and involvement in mathematics-related activities. Students start to develop a stigma against mathematics by the end of elementary school. Outreach events...
Arsenic in its inorganic form is naturally present in groundwater. Continued exposure to arsenic contaminated water can result in long lasting health complications, ranging from cognitive development issues to cancer. One method which may be convertible to a field test is the use of PEG functionalized gold nanoparticles which aggregate...
Coral reefs are diverse ecosystems and serve many purposes including preventing erosion on coastlines and acting as a source of food, income, and culture. Acropora cervicornis, a staghorn coral, has faced a significant 80-89% decline in the Caribbean, attributed to a poorly-characterized epizootic, White Band Disease (WBD). Previous studies showed...
The photophysical properties of two-dimensional (2D) layered van der Waals (vdW) materials, and their heterostructures are manifestly distinct from crystalline bulk materials. Recently, the discovery of new 2D vdW materials and strongly-bound interlayer excitons in these materials has created a new branch in nanoscience. As such, there are a number...