Occlusive thrombi that cause cardiovascular diseases form on the walls of blood vessels and propagate across the lumen under pressure gradient-driven flow, impaired antithrombotic, and enhanced prothrombotic conditions. Development of a well controlled and validated ex vivo model that can mimic these pathological conditions would provide a useful tool for...
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shear rate of 325 s-1. Times for occlusions were measured from the moment blood exited the capillary
Occlusive thrombi that cause cardiovascular diseases form on the walls of blood vessels and propagate across the lumen under pressure gradient-driven flow, impaired antithrombotic, and enhanced prothrombotic conditions. Development of a well controlled and validated ex vivo model that can mimic these pathological conditions would provide a useful tool for...
Full Text:
height of 3 cm (hb), the pressure gradient caused
by gravity gave an initial shear rate of 325 s-1
Organic aerosols are important atmospheric components, and their formation and sources represent important aspects of urban air quality and health effects. Asia, including India, is the largest global source of aerosol particles due to regional natural advection (e.g. desert and soil dust) and anthropogenic activities (e.g. emissions from traffic, industry...
Cystic fibrosis is an inherited genetic disease caused by a single gene mutation in the CFTR protein. Affecting 70,000 people worldwide, this disease is debilitating to patients, resulting in persistent lung infections and decreased quality of life. Due to the various mutation types, there is not currently a single drug...
Mathematics outreach typically consists of community events that show the exciting applications of mathematics, particularly to K-12 students. The goal of mathematics outreach events is to increase student interest and involvement in mathematics-related activities. Students start to develop a stigma against mathematics by the end of elementary school. Outreach events...
When vessel walls within the vasculature are damaged, exposed extracellular
matrix (ECM) proteins trigger a series of events that lead to the formation of a
hemostatic plug (Andrews et al. 2004, Furie et al. 2008, Watson 2009). Thrombus
formation requires an orchestrated series of receptor-mediated events facilitating platelet
recruitment, platelet...
Mycobacterium avium subsp. paratuberculosis (MAP) is a cause of
Johne's disease (JD) in cattle and other ruminants. MAP infection in the bovine
host is not well characterized. It is assumed that crossing the bovine intestinal
mucosa is important for MAP to establish infection. MAP's ability to infect
bovine epithelial cells...
Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
There has been increased concern about radiation dose to the female breasts, with approximately 200,000 new breast cancers being diagnosed each year in the United States. The unprecedented increase in the use of radiologic exams on younger women has also raised some additional concerns about how procedures are performed. The...
Arsenic in its inorganic form is naturally present in groundwater. Continued exposure to arsenic contaminated water can result in long lasting health complications, ranging from cognitive development issues to cancer. One method which may be convertible to a field test is the use of PEG functionalized gold nanoparticles which aggregate...