Research poster for Summer Undergraduate Research Symposium 2019. Research was conducted with CURE funding in the Perez lab studying cellular senescence in the PS19 mouse model.
Aging is a major risk factor for the deterioration of biochemical pathways that lead to many chronic neurodegenerative disorders (i.e. Parkinson’s and Alzheimer's Disease). Cellular senescence is a hallmark of aging, a condition characterized by stable growth arrest resulting in a cell that no longer divides, but is metabolically active....
Aging is a process that all living species experiences and it also is greatly to study and understand the aging process with the aim of extending human life span. Protein homeostasis is one of the main hall mark of aging. Based on previous data, it observed that cells from long...
The role of the high density lipoprotein (HDL) molecule is currently an area of great interest within the scientific community. Previously, mouse and human studies have demonstrated an inverse association between HDL cholesterol (HDL-C) levels and cardiovascular disease. Recent clinical trials, which increased HDL-C, have failed to reduce the number...
The loss of proteostasis is the mechanism for maintaining properly folded proteins and degrading misfolded ones. One protective mechanism against loss of proteostasis is the Unfolded Protein Response (UPR), a chaperone mediated folding system in the Endoplasmic Reticulum (ER). The UPR communicates with the Nrf2 pathway, a transcription factor, and...
Many people die yearly worldwide due to diseases associated with aging, and if the
process of aging in humans was more understood, the health of these patients could be
improved. While many biochemical actions are involved with the aging process, loss of
proteostasis has been called one of the most...
Phylogenic studies suggest that cells from long-lived species are more resistant to a variety of stressors than short-lived species. However, there is little information on the cellular mechanisms that give rise to increased resistance to stress. Our previous studies have shown that liver proteins from a long-lived species have lower...
Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...