Mycobacteriosis is a common disease of laboratory zebrafish (Danio rerio). Different infection patterns occur in zebrafish depending on mycobacterial species. Mycobacterium marinum and M. haemophilum produce virulent infections associated with high mortality, whereas M. chelonae is more wide spread and not associated with high mortality. Identification of mycobacterial infections to...
During the past decade the zebrafish has emerged as a leading model for mechanistic cancer
research due to its sophisticated genetic and genomic resources, its tractability for tissue
targeting of transgene expression, its efficiency for forward genetic approaches to cancer model
development, and its cost-effectiveness for enhancer and suppressor screens...
Gravid adult female Euphausia pacifica were collected off Newport, Oregon, USA and transferred to the laboratory, where females spawned eggs, eggs hatched, and larvae were reared at 10.5 degrees C. We fed 4 cohorts of larvae to excess with a combination of phytoplankton species and monitored them daily until they...
Mycobacteriosis is a common disease of laboratory zebrafish Danio rerio. Different infection patterns occur in zebrafish depending on mycobacterial species. Mycobacterium marinum and M. haemophilum produce virulent infections associated with high mortality, whereas M. chelonae is more widespread and is not associated with high mortality. Identification of mycobacterial infections to...
Infection with Helicobacter pylori is a major risk factor for the development of gastric cancer, and infection with strains carrying the virulence factor CagA significantly increases this risk. To investigate the mechanisms by which CagA promotes carcinogenesis, we generated transgenic zebrafish expressing CagA ubiquitously or in the anterior intestine. Transgenic...
We are conducting studies on the impacts of parasites on Oregon coastal coho salmon (Oncorhynchus kistuch). An essential first step is documenting the geographic distribution of infections, which may be accomplished by using different methods for parasite detection. Thus, the objectives of the current study were to (1) identify parasite...
We compared brood sizes among adult female Euphausia pacifica Hansen, 1911 from 3
populations in the North Pacific: Puget Sound, Washington, USA; Toyama Bay, Japan; and the Oregon coast, USA. Additionally, we used multiple linear regression models to compare the interspecific brood size as a function of female length and...
Spontaneous neoplasia of the intestinal tract in sentinel and moribund zebrafish (Danio rerio) is common in some zebrafish facilities. We previously classified these tumors as adenocarcinoma, small-cell carcinoma, or carcinoma otherwise unspecified based on histomorphologic characteristics. Based on histological presentation, the primary differential diagnosis for the intestinal carcinomas was tumor...
Atrazine (ATZ) is a selective triazine herbicide used primarily for pre-emergent weed control in corn, sorghum and sugar cane production. It is one of the most widely used herbicides in North America. Some research published over the last decade suggests that chronic exposure to environmentally relevant ATZ concentrations can adversely...