In a search for new therapeutic agents, a series of Mannich bases
derived from the following 2-phenylindolizines were prepared: 2-phenylindolizine, 1, 2-diphenylindolizine, 3-methyl-2-phenylindolizine,
3-ethyl-2-phenylindolizine, and 1-(2-hydroxyethyl)-2-phenylindolizine.
The investigation was based on the speculation that indolizine
analogs of physiologically active indoles might be useful medicinally.
A certain group of indoles, all...
In a two part thesis, studies were made of two
different types of structure-activity relationships.
The first part consists of the synthesis and biological
evaluation of a number of 4-substituted pyrazoles and
isoxazoles as inhibitors of liver alcohol dehydrogenase.
In an effort to better define the steric and electronic
effects...