The entire human population is chronically exposed to various
contaminants, including lead and chlorinated hydrocarbon pesticides.
Studies were undertaken to assess the effects of chronic exposure to
lead on the toxicities of two such pesticides, lindane and dieldrin.
Mice were given lead as the acetate in drinking water, at levels...
Investigations were undertaken to characterize the toxicity in
animals treated with 1, 3-Bis(2-chloroethyl)-1-nitrosourea (BCNU).
Primary experimental interest in this compound had centered around
its antineoplastic activity; however, clinical application of the compound
resulted in the appearance of delayed toxicity symptoms. A
critical evaluation of the toxicity associated with BCNU has...
Rats given morphine-codeine combinations exhibited significantly
increased hotplate reaction times compared with rats given
an analgesic dose of one agent alone. Genera, species, sex, protein
binding and metabolism were studied as possible implicating factors
for the increased reaction times. Both male and female rats exhibited
increased reaction time, and showed...
Studies were initially conducted to determine the action of
intravenous serotonin on perfused segments of human umbilical
cords in vitro. Intravenous serotonin, via bolus injection or
continuous infusion, was found to elevate venous perfusion pressure,
while intra-arterial serotonin failed to alter venous pressure.
Norepinephrine, administered to the venous perfusate, was...
Electrical stimulation of the vagus nerves produces an excitatory
contraction response in the isolated rat stomach. This contraction
response was abolished by atropine to unmask the vagal inhibitory
response (VIR) elicited during low frequency vagal stimulation.
Babring and Gershon (1967), after working on guinea-pigs and mice,
hypothesized that both serotonin...