Particles generated from wear of prosthesis joint bearing surfaces induce inflammation and promote pathological periprosthetic osteoclast-mediated bone resorption (osteolysis). Obesity increases the risk of prosthesis failure. However, despite being morbidly obese, leptin-deficient ob/ob mice are resistant to osteolysis. These findings suggest that leptin exerts effects that act to increase particle-induced...
A major barrier to air travel for people with disabilities is the general lack of accessible lavatories on board commercial passenger aircraft. A primary reason for this lack of greater accessibility is related to space. To design an airplane lavatory that is accessible, minimizes the risk of injury to both...
Research has shown that stress is related to
negative physical and psychological changes among
adults. Compared to the large body of literature on
stress among adults, research on the effects of life
stress among children and adolescents is relatively
sparse. There is evidence, however, that stressful
life events are related...
The need to detect trace amounts of target molecules is great, particularly when it comes to biosensing. With the early detection of a disease, the odds of the successful treatment of an individual increases significantly. To enhance the capability of biomolecular detection, we have created an optical biosensor capable of...
A prototype real-time process monitoring emergency
classification expert system, RT/EM-CLASS, has been developed
for use at the Trojan Nuclear Power Plant. This knowledge-based
system features the integration of electronically sensed plant
data with the menu selection data representation of its
predecessor, EM-CLASS. This prototype demonstrates the
techniques required to acquire...
This dissertation focuses on the application of diatom frustules, the biosilica shell of an algae possessing physical and photonic properties capable of enhancing optical signals, for the enhancement of optical sensing. In this work, we incorporate diatom frustules into biosensors for signal enhancement and improved target molecule detection. The potential...