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  • DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

    Creator:
    Hooven, Louisa Ada
    Abstract:
    Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
    Resource Type:
    Dissertation
    Full Text:
    : William M. Baird Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been

  • Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

    Creator:
    Knecht, Andrea L.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
    Resource Type:
    Dissertation
    Full Text:
    . Gale, S. L., E. M. Noth, et al. (2012). "Polycyclic aromatic hydrocarbon exposure and wheeze in a

  • Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

    Creator:
    Goodale, Britton C.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
    Resource Type:
    Dissertation
    Full Text:
    ...................................................................................................... 23 Figure 1-3 Polycyclic aromatic hydrocarbon structures

  • Advances in Passive Sampling : Measuring Chemical Transport and Human Exposures

    Creator:
    Donald, Carey E.
    Abstract:
    Passive sampling devices have been used for decades to measure complex mixtures of bioavailable organic chemicals in a variety of environmental media. More recently passive sampler applications have expanded beyond monitoring chemical concentrations, and this dissertation continues to advance methods of passive sampling on many fronts. Despite their growing use,...
    Resource Type:
    Dissertation
    Full Text:
    contaminants can be defined by their source, as with polycyclic aromatic hydrocarbons (PAHs) that are

  • Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

    Creator:
    Madeen, Erin
    Abstract:
    The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
    Resource Type:
    Dissertation
    Full Text:
    High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and

  • Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

    Creator:
    Chlebowski, Anna C.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
    Resource Type:
    Dissertation
    Full Text:
    Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity Abstract approved

  • Human exposure to polycyclic aromatic hydrocarbons : global cancer risk and metabolism

    Creator:
    Motorykin, Oleksii
    Abstract:
    In recent decades, there has been increased attention on human exposure to, and subsequently toxicity of, Polycyclic Aromatic Hydrocarbons (PAHs). PAHs are widespread organic pollutants and some have been shown to be toxic, carcinogenic and mutagenic. This research was focused on understanding the link between global PAH emissions and lung...
    Resource Type:
    Dissertation
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    ................................................................................................... 7 2. ASSOCIATION OF CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBON EMISSIONS AND SMOKING WITH LUNG

  • Photo-enhanced Toxicity of Oil Constituents and Corexit 9500 to Gulf of Mexico Marine Organisms

    Creator:
    Finch, Bryson E.
    Abstract:
    Significant inputs of hydrocarbons are continually released into the environment from anthropogenic and natural sources. Some of the most toxic hydrocarbon compounds are polycyclic aromatic hydrocarbons. Polycyclic aromatic hydrocarbons are known for their ability to absorb ultraviolet light and enhance toxicity. Generally, PAHs exert their toxicity via narcosis but UV-absorbing...
    Resource Type:
    Dissertation
    Full Text:
    are polycyclic aromatic hydrocarbons. Polycyclic aromatic hydrocarbons are known for their ability

  • Adapting computer science technologies to bridge critical gaps in proposed Tox21 risk assessment programs

    Creator:
    Larkin, Andrew
    Abstract:
    In 2004 the National Toxicology Program published an article describing their intent to pursue toxicology testing and risk assessment practices solely reliant on high throughput in vitro datasets and in silico modeling for dose-response assessments. Support and contributions form regulatory agencies and a significant portion of the life sciences community...
    Resource Type:
    Dissertation
    Full Text:
    . Development of a fuzzy neural network model for predicting polycyclic aromatic hydrocarbon-mediated

  • Synthesis, characterization, and analysis of nitroaromatic compounds

    Creator:
    McIntosh, Melissa Luana
    Abstract:
    Nitroaromatic compounds have important chemical applications and can be found in nature as pollution sources. Synthetic nitroaromatic compounds have been used in a variety of materials including explosives, pharmaceuticals, dyes, plastics, and pesticides. These compounds can find their way into the environment through normal or improper disposal methods. Poly-aromatic compounds...
    Resource Type:
    Masters Thesis
    Full Text:
    disclosed. Nitro-polycyclic aromatic hydrocarbons (NPAHs) are potential carcinogenic compounds found