Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
Introduction: In today's radiological quest to pacify and eliminate cancer, it has become conventional in cancer treatment facilities to implement advanced guidance or target localization systems with the goal of maximizing accuracy of radiation dose delivery to a tumor while simultaneously minimizing normal tissue complication. At the Oregon Health &...
Zinc is an essential mineral that is integral to many proteins and transcription factors that regulate key cellular functions. The normal prostate accumulates high concentrations of zinc; however, malignant tissues have significantly lower zinc levels. This unique relationship between zinc and the prostate has sparked interest in the role of...
Methylthioadenosine (MTA) is a naturally occuring nucleoside formed during
the synthesis of polyamines in mammalian cells. MTA is rapidly catabolised
by MTA phosphorylase (MTAase), eventually yielding methionine and
adenine. MTAase has been shown to be active in all normal cells, but
deficient in some cells and tissues of malignant origin....
The number of women living with a breast cancer diagnosis will continue to increase with growing breast cancer incidence rates, greater utilization of early detection, and longer length of survival times. The prevalence of complementary and alternative medicine (CAM) is likely to increase as well, making it important to determine...
Prostate cancer is the most commonly diagnosed cancer in men, but rates around the world vary greatly. Americans have the highest incidence rates in the world, 4 to 5 times those of Spain. The hypothesis of this thesis was that vitamin D metabolism is a factor in prostate cancer development...
Prostate cancer is responsible for a substantial loss of life and burden of suffering among adult males. Evidence suggests that the risk of morbidity and mortality from prostate cancer can be reduced through specific screening and dietary practices (MCI, 2002; Ries et al., 2002). Further evidence suggests that screening can...
Prostate cancer risk is significantly lower in Asian countries compared to the US, which has prompted interest in the chemo-preventative action of dietary components such as soy and green tea commonly found in Asian diets, such as soy and green tea. Studies have suggested that soy isoflavones and green tea...
Approximately 12% of Americans do not consume the amount of zinc equal to the Estimated Average Requirement for zinc and could be at risk for marginal zinc deficiency. Zinc is an essential component of proteins in the defense against oxidative stress and DNA damage repair. Specifically in the prostate, zinc...