Index Catalog // ScholarsArchive@OSU

Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

Creator:: Nazari, Mohamad
Abstract:: Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
Resource Type:: Dissertation
Full Text:: would like to thank the rest of my graduate committee: Prof. Phil Proteau, Prof. Jane Ishmael, and

Natural products from temperate and tropical marine algae

Creator:: Graber, Melodie A.
Resource Type:: Masters Thesis
Full Text:: . Constantine, Philip J. Proteau and Douglas Markle for their advice and assistance. I especially thank Dr

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Creator:: Blanchard, David, L.
Abstract:: L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
Resource Type:: Dissertation
Full Text:: : Dr. Philip Proteau, Dr. Taifo Mahmud, Dr. Xihou Yin, and Dr. Thomas Savage for their proofreading

Broadening the scope of the modified-Julia reaction : a mild and stereoselective method for the synthesis of (Z)-configurated α,β-unsaturated lactones

Creator:: Giesbrecht, Heath Eugene
Abstract:: An intramolecular variant of the modified-Julia olefination was demonstrated by the synthesis of α,β-unsaturated lactones in a mild and (Z)-selective fashion. The lynchpin reagent (benzothiazol-2-sulfonyl) acetic acid was synthesized in a straightforward fashion in 86% overall yield from commercially available 2-mercaptobenzothiazole via conversion to ethyl (benzothiazol-2-ylthio)acetate by base mediated alkylation...
Resource Type:: Masters Thesis

Development of Methods for Stereoselective Carbon-Carbon Bond Formation

Creator:: Wu, Zhenhua
Abstract:: Three distinct methods to achieve the stereoselective synthesis of carbon-carbon bonds were investigated, encompassing: (i) the formation of axially chiral biaryl molecules by enantioselective Suzuki cross-coupling, (ii) the synthesis of α-phenylalkylboronic esters by enantioselective chain extension, and (iii) the stereospecific synthesis of alkenes by eliminative cross-coupling of enantioenriched sp³-hybridized carbenoids....
Resource Type:: Dissertation
Full Text:: influence on me. I wish to thank my committee members Dr. Rich Carter, Dr. Kevin Gable, Dr. Philip

Biosynthesis and modification of the antibiotic enduracidin

Creator:: Goebel, Neal C.
Abstract:: The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
Resource Type:: Dissertation
Full Text:: Mahmud. Phil Proteau and Kerry McPhail. It has been a privilege to have worked with you. The advice and

Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

Creator:: Melbardis, John
Abstract:: In previous work (Blakemore et al. Org. Lett. 2005, 7, 4721; Heterocycles 2006, 70, 609), successful elaborations of the lupine alkaloids (±)-α-isosparteine (dl-2) and (±)-β-isosparteine (dl-3) were realized from a common tetraoxobispidine precursor, 3,7-diallyl -2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (93). Herein, the tetraoxobispidine approach to lupine alkaloids was extended to a total synthesis of...
Resource Type:: Masters Thesis

Evaluation of different monitoring strategies for public health protection : harmful algal bloom surveillance at Devils Lake, Lincoln City, OR

Creator:: Hitchko, Kara L.
Abstract:: Cyanobacteria are photosynthetic bacteria capable of producing toxins, including complex cyclic peptides called microcystins. Hazardous cyanobacterial blooms are an emerging public health concern and are monitored throughout Oregon in various recreational and drinking water bodies. Oregon has been proactive and responsive to the problems associated with toxic cyanobacterial blooms, but...
Resource Type:: Masters Thesis
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1) Preparation of Acetaminophen Capsules Containing Beads Prepared by Hot-melt Direct Blend Coating Method 2) Pharmacokinetic Modeling and Monte Carlo Simulations in The Context of Additional Criteria for Bioequivalence Assessments 3) Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and its Association to Tendinopathy

Creator:: Pham, Loan
Abstract:: The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Resource Type:: Dissertation
Full Text:: committee members, Dr. Rosita R. Proteau, Dr. Philip J. Proteau, Dr. Alix I Gitelman and Dr. Christine

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Creator:: Hardardt, Elizabeth Ann
Abstract:: This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
Resource Type:: Masters Thesis
Full Text:: ” Rochefort, Phil Proteau and Adrian “Fritz” Gombart, and all the researchers who developed the use of

ScholarsArchive@OSU

Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

Natural products from temperate and tropical marine algae

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Broadening the scope of the modified-Julia reaction : a mild and stereoselective method for the synthesis of (Z)-configurated α,β-unsaturated lactones

Development of Methods for Stereoselective Carbon-Carbon Bond Formation

Biosynthesis and modification of the antibiotic enduracidin

Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

Evaluation of different monitoring strategies for public health protection : harmful algal bloom surveillance at Devils Lake, Lincoln City, OR

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

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