Protein-protein interactions underlie all biological processes and are a field of study that has wide implications throughout many other fields including medicine, genetics, biology, and ecology. Proteins are the building blocks and primary actors of life. They work together to accomplish virtually every task within a cell, including, metabolism, signal...
Protein secondary structure prediction plays a pivotal role in predicting protein folding in three-dimensions. Its task is to assign each residue one of the three secondary structure classes helix, strand, or random coil. This is an instance of the problem of sequential supervised learning in machine learning. This thesis describes...
The finite element software framework, OpenSees, has been used by researchers
to simulate the response of structural and geotechnical systems to earthquake loading. Implementation of the Particle Finite Element Method (PFEM) has made it possible to simulate hydrodynamic forces through fluid-structure interaction (FSI) in OpenSees. To validate the FSI implementation...
Fluid-structure interaction (FSI) is an interesting and challenging interdisciplinary area comprised of fields such as engineering- fluids/structures/solids, computational science, and mathematics. FSI has several practical engineering applications such as the design of coastal infrastructure (such as bridges, levees) subjected to harsh environments from natural forces such as tsunamis, storm surges,...
This paper presents an empirical approach for measuring and characterizing the responsiveness of a character to changes in goal. Our approach is based on keeping track of the character's progress towards a frequently changing goal. A "distance-to-goal" function is defined to measure the progress. We then calculate an asymptotic proportion...
The fluid impact forces on a bridge superstructure in horizontal and vertical directions due to tsunamis represented by solitary waves are investigated through a large-scale laboratory experiment and numerical simulations. The experiment is conducted in a two-dimensional wave basin using a 1:5 scaled reinforced concrete bridge deck model tested under...
As computational power increases, so does the desire to use fluid-structure interaction (FSI) software to design complex systems and components such as fuel plates. Presently, an effort is underway to support the design and qualification of a new nuclear fuel material which is intended for applications in select, plate-type, research...
Degradation of watersheds is a major concern in areas where adverse climate effects and unsustainable use of the natural resources have caused extensive stresses to watershed systems (e.g., increased floods, increased droughts, worsened in-stream water quality) through the years. While considerable efforts are being made to generate technical solutions that...