Previous studies have shown that rainbow trout exposed to dieldrin via diet for 9 to 12 weeks increased biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500%. This was not explained by induction of the cytochrome P-450 (CYP) system involved in oxidative metabolism of these compounds. We hypothesized that...
Numerous tests were applied to rainbow trout
of eleven months of age to determine whether
ascorbic acid is an essential element of the diet
of these fish. Although previous work had been
done on this question, conflicts in the results,
the large reliance upon abnormal symptoms such as
lordosis and...
The peripheral-type benzodiazepine receptor (PTBR) of trout brain was
pharmacologically characterized and pyrethroid interaction with this site
investigated. High-affinity binding sites for [³H]PK 11195 were detected in brain
membranes of rainbow trout; these shared some of the characteristics of the
PTBR of rodent brain (i.e., high affinity for PK 11195...
Dimethylbenz (a) anthracene (EMBA), a carcinogen that requires
metabolic activation to produce active metabolites capable of
binding to DNA, has been studied in the trout and other fish.
Polycyclic aromatic hydrocarbons (PAH) are of importance as they
are ubiquitous in the environment and their carcinogenic effects
in fish from contaminated...
The DNA repair capabilities of rainbow trout (Salmo gairdneri)
were studied vising the method of autoradiography. Trout were fed a
semi-purified control diet containing 0 ppm, 50 ppm, or 300 ppm
cyclopropenoid fatty acids (CPFA) for 6-9 weeks. Liver slices were
prepared and exposed in vitro to a control treatment,...
Experiments were conducted to determine survival, growth, and accumulation of HEOD (major component of dieldrin) in the tissues of steelhead trout (Salmo gairdneri) embryos, alevins, and fry exposed to dieldrin concentrations ranging from 0.012 to 52 ppb. The fish were held in specially designed exposure chambers provided with continuously renewed...
Currently little is known about the mechanisms and locations of
lymphocyte development in teleosts. In this study several aspects of the
underlying factors which govern B lymphocyte development in trout
were investigated which included: the isolation and characterization of
immunoglobulin heavy chain (IgH) genes, the recombination activating
genes 1 and...