Mammals exhibit circadian rhythms in several physiological processes
controlled by a core set of circadian genes that make up the so-called molecular
clock. Disruptions in these rhythms, and variations in circadian genes, are associated
with the development of psychiatric disorders, including addiction. However, the
effect of chronic binge-like alcohol drinking...
The preconditioning agent poly-ICLC has recently been shown to protect against cerebral injury in the mouse model, when administered systemically prior to ischemic insult. However, the mechanism by which poly-ICLC provides neuroprotection is currently unknown, but it has been shown to protect against ischemia-induced bloodbrain barrier (BBB) disruption. Inflammation contributes...