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KangYukiLPIHDAC8STAT3Repress_SupplementaryMaterials.zip

Creator:

Kang, Y., Nian, H., Rajendran, P., Löhr, C. V., Bisson, W. H., Williams, D. E., and et al.

Abstract:

Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
KangYukiLPIHDAC8STAT3Repress.pdf

Creator:

Kang, Y., Nian, H., Rajendran, P., Löhr, C. V., Bisson, W. H., Williams, D. E., and et al.

Abstract:

Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...

Full Text:

., Rajendran, P., Kim, E., Dashwood, W. M., Pinto, J. T., ... & Dashwood, R. H. (2014). HDAC8 and STAT3
HDAC8 and STAT3 repress BMF gene activity in colon cancer cells

Creator:

Kang, Y., Nian, H., Rajendran, P., Kim, E., Dashwood, W. M., Pinto, J. T., Boardman, L. A., Thibodeau, S. N., Limburg, P. J., Löhr, C. V., Bisson, W. H., Williams, D. E., Ho, E., and Dashwood, R. H.

Abstract:

Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...

Resource Type:

Article