Index Catalog // ScholarsArchive@OSU

Assessing an Adult Zebrafish Model for In Vivo Delivery of Morpholino Oligomers

Creator:: Kim, Joseph Y.
Abstract:: Antisense morpholino oligomers are synthetic macromolecules can modify gene expression. While these compounds have great potential to treat a broad range of human diseases, they suffer from poor cellular delivery. Conjugating cell-penetrating peptides onto these morpholinos is one option of addressing delivery, however development remains slow due to the cost...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Robert Tanguay, Committee Member, representing Environmental & Molecular Toxicology

Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Creator:: Sidebotham, Nicole A.
Abstract:: A study was conducted to evaluate the developmental toxicity of three commonly detected mycotoxins in food (deoxynivalenol, patulin, and zearalenone) using the zebrafish (Danio rerio) model. Mycotoxin exposures were carried out at five concentrations (0.0064, 0.064, 0.64, 6.4, and 64 μM). Morphological and photomotor screenings were conducted at 24 hours...
Resource Type:: Honors College Thesis
Full Text:: Robert Tanguay, Committee Member, representing the Department of Environmental and Molecular Toxicology

Integration of embryonic zebrafish and passive sampling device extracts to explore effects of pesticide mixtures

Creator:: Corvi, Margaret
Abstract:: Pesticides are ubiquitous, with more than one billion tons of pesticide products used in the United States annually. These compounds are characterized by their toxic effects to the target organism; however, pesticides are also well known for their deleterious effects to non-target species. Because pesticides have ecological and human health...
Resource Type:: Undergraduate Thesis and Presentation

Analysis of Cancer Progression by Establishing Quantitative Assessments of Zebrafish Xenografts

Creator:: Gamble, John T.
Abstract:: The goal of this dissertation was to improve our abilities in acquiring critical in vivo data by establishing embryo-larva zebrafish as an exemplary model to quantitatively evaluate cancer progression. The living environment that encompasses a tumor has a significant effect on how cancer develops, grows and metastasizes. In order to...
Resource Type:: Dissertation
Full Text:: needed zebrafish last minute. Also, I cannot forget to thank Robert Tanguay for his advice and help

Automated manipulation of zebrafish embryos for high-throughput toxicology screening of nanomaterials

Creator:: Mandrell, David
Abstract:: The field of nanotechnology has been rapidly developing new materials. These materials have become incorporated into consumer products and the environment after only minimal assessment of their effects on human health or the environment. The toxicity of these new nanomaterials remains unknown due to the unpredictable nature of the core...
Resource Type:: Masters Thesis
Full Text:: to thank Dr. Robert Tanguay for giving me the opportunity to work on a project that I have truly

The use of natural plant extracts as a feed additive to prevent laminitis in lactating dairy cows

Creator:: Pierson, Miranda L.
Abstract:: Two experiments were conducted looking at both acute and sub-acute laminitis. An acute nutritional induction model was used to examine whether blood profiles and gene expression are similar to other studies conducted using an endotoxin induction model. Twelve sheep were randomly assigned to three treatment groups which were control, 4-hour...
Resource Type:: Masters Thesis
Full Text:: Mike Gamroth and Dr. Robert Tanguay for joining my graduate committee on such short notice. I would

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: committee members, Drs. Andrew Buermeyer, Robert Tanguay, David Williams, and Anna Harding, for their

Pseudoloma neurophilia in the Zebrafish (Danio rerio) : Consequences of Infection on Neurobehavioral and Biomedical Research using a Burgeoning Model Organism

Creator:: Spagnoli, Sean
Abstract:: Since its inception as a laboratory animal in the early 1970s, the zebrafish has proven itself a rising star in the world of comparative biomedical sciences due to its short generation time, ease of care, external fertilization, and transparent larvae. In a very few decades, the zebrafish has been utilized...
Resource Type:: Dissertation
Full Text:: , Jerry Heidel, David Noakes, and Robert Tanguay who provided both guidance and support throughout the

Systematically evaluating the developmental toxicity of nanomaterials using the zebrafish model

Creator:: Edwards, Sabrina R.
Abstract:: As engineered nanomaterials (ENM) become more common in consumer products, it is crucial to rapidly assess toxicity of unique ENM. Previous studies rarely focused on standardizing nanotoxicity testing, leading to inconsistent and irreproducible results. This study characterized a variety of ENM of different size, shape, core type, and surface charge...
Resource Type:: Poster, Undergraduate Thesis, and Presentation
Full Text:: Environmental and Molecular Toxicology Oregon State Toxicology Dr. Robert Tanguay Sinnhuber Aquatic Research Lab

Advancement of Passive Sampling Applications for Assessing Contaminant Transport, Bioaccumulation, and Toxicity

Creator:: Minick, David J.
Abstract:: In the environment, it is the unbound fraction of chemical (Cfree) which is able to diffuse across environmental interfaces and biological membranes. It is therefore Cfree which drives many important biological-environmental processes including contaminant transport, bioaccumulation and toxicity. Passive sampling devices (PSDs) offer a simplified and more accurate approach for...
Resource Type:: Dissertation
Full Text:: . Robert Tanguay, and Dr. Michelle Odden. I’d also like to thank my undergraduate professors: Dr. Jeffrey

ScholarsArchive@OSU

Assessing an Adult Zebrafish Model for In Vivo Delivery of Morpholino Oligomers

Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Integration of embryonic zebrafish and passive sampling device extracts to explore effects of pesticide mixtures

Analysis of Cancer Progression by Establishing Quantitative Assessments of Zebrafish Xenografts

Automated manipulation of zebrafish embryos for high-throughput toxicology screening of nanomaterials

The use of natural plant extracts as a feed additive to prevent laminitis in lactating dairy cows

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Pseudoloma neurophilia in the Zebrafish (Danio rerio) : Consequences of Infection on Neurobehavioral and Biomedical Research using a Burgeoning Model Organism

Systematically evaluating the developmental toxicity of nanomaterials using the zebrafish model

Advancement of Passive Sampling Applications for Assessing Contaminant Transport, Bioaccumulation, and Toxicity

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