The discovery of GW170817 provided the first empirical evidence that merging binary neutron star systems are both progenitors of short gamma-ray bursts, as well as the primary sites of the nucleosynthetic rapid-neutron capture process. Initially detected as gravitational wave (GW) and gamma-ray burst (GRB) triggers, GW170817 was well-localized and follow-up...
Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
The goal of this dissertation is to investigate the interaction between cimetidine and dietary flavonoids using the Caco-2 cell transport model. It has been shown that flavonoids can change the bioavailability of pharmaceuticals, either by inhibiting metabolizing enzymes or inhibiting the drug efflux transporters. However, the effect of dietary flavonoids...
The life cycle assessment (LCA) process is a systematic approach to determining the environmental impacts of different products and processes. LCA is a relative approach that requires functional equivalence for the results to be compared. A method is presented that achieves functional equivalence by equating the reliability indexes being compared....
Potato Virus Y (PVY) imposes serious limitations on potato yield, quality and tuber seed
production. Traditional PVY screening requires artificial inoculation under controlled
conditions followed by ELISA to test for PVY. This method is very tedious and time
consuming thus prohibiting the screening of large segregating populations. The genes
RYadg...
The number of Latinx students enrolling in higher education has grown significantly over the past two decades (Jabbar et al., 2019). This study explores a portion of that population by focusing on the experiences of Latinx transfer students at a 4-year institution within the Pacific Northwest of the United States....
Inoculations of white fir, Shasta red fir, Douglas fir and
ponderosa pine with Pisolithus tinctorius spores when outplanted
failed to produce P. tinctorius mycorrhizae at the end of the first
growing season. In the third year a few P. tinctorius mycorrhizae
were formed on white fir. Inoculations reduced seedling survival...
“Active carbon” is a rapidly cycling soil organic carbon (SOC) fraction that acts as an energy and nutrient source for the microbial community. Dilute permanganate oxidation has been used to measure an “active carbon” fraction with the assumption that permanganate oxidation mimics enzymatic decomposition. Permanganate oxidizable carbon (PoxC) has become...
Type 2 Diabetes Mellitus is a chronic metabolic condition that impairs insulin stimulated glucose absorption in skeletal muscle, a characteristic phenomenon denoted as insulin resistance. Lipid overload of the mitochondria is linked to the development of insulin resistance and the progression of Type 2 Diabetes. As lipids accumulate there is...
In Oregon, outdoor recreation activities have continued to grow in popularity, as has the overall Latin@ population of the state. With the continual population increase of this ethnic group, researchers have focused on understanding their outdoor recreation habits through an environmental justice lens. This includes accessibility, affordability, and other barriers...