Using published dairy cattle liver transcriptomics dataset along with novel blood biomarkers of liver function, metabolism, and inflammation we have attempted an integrative systems biology approach applying the classical functional enrichment analysis using DAVID, a newly-developed Dynamic Impact Approach (DIA), and an upstream gene network analysis using Ingenuity Pathway Analysis...
The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
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Sandra Loesgen
Fungi have long been a prolific source of clinically approved drugs. The
Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Pollination is an essential ecosystem service that sustains functioning ecosystems and aids in food production. In response to recent, widespread declines of managed and native bee populations, many land managers have shown interest in developing conservation and restoration plans for enhancing native bee habitat. However, there is a lack of...
In a story of his life Les reflects on what he
has gained and what he has lost while seeking success in
the moving and shifting of military and academic life
through homes and schools all over the United States.
He describes himself as between races, languages, and
cultures.
The purpose of this study was to explore some of the practices
of home economics teachers in the use of auxiliary personnel as
expressed by city and state supervisors. A second purpose was to
discover the beliefs of city and state supervisors regarding the use
of auxiliary personnel in home...
These studies examined the role of perinatal androgen
in the development of neuroendocrine and behavioral
characteristics of gray-tailed voles, Microtus
canicaudus. When mature, females exhibited alternating
vaginal smear patterns or persistent vaginal
cornification; estrogen and progesterone concentrations
were not correlated with vaginal smear patterns. Corpora
lutea were not observed in...
A sensory method was developed to determine cheese texture by hand evaluation. Cheese sensory evaluation was conducted by panelists (n=8) on four commercial samples in duplicates. Standards, descriptors, methods of each attribute evaluation, sample size, and ballot were developed based on panelists' consensus. Fifteen total attributes, divided into five groups,...