We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large intercompartmental backbones. The deviations were exaggerated in lamina-associated...
Enabled by a rich ecosystem of Machine Learning (ML) libraries, programming using learned models, i.e., Software-2.0, has gained substantial adoption. However, we do not know what challenges developers encounter when they use ML libraries. With this knowledge gap, researchers miss opportunities to contribute to new research directions, tool builders do...
The numerical modeling of motions in the atmosphere's
planetary boundary layer (PBL) is a challenging task. In
general, the boundary layer interacts with both the overlying
atmosphere and the underlying land or water surface
in a complex manner. Random turbulence is also present in
the PBL which precludes exact prediction...
Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...