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Filtering by: Funding statement SLH acknowledges NIH grants ES017552-01A2, ES016896-01, P30 ES03850, T32 ES0007060, and AFRL FA8650-05-1-5041. JDN acknowledges National Institutes of Health/National Institute of Allergy and Infectious Diseases grant 1RC2A1087612-01. AJF acknowledges Dermatology Foundation Career Development Award and Janssen Biotech Research Grant.

S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology

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Mordorski, Breanne, Pelgrift, Robert, Adler, Brandon, Krausz, Aimee, da Costa Neto, Alexandre Batista, Liang, Hongying, Gunther, Leslie, Clendaniel, Alicea, Harper, Stacey, Friedman, Joel M., Nosanchuk, Joshua D., Nacharaju, Parimala, and Friedman, Adam J.

Abstract:

Nitric oxide (NO) is an essential agent of the innate immune system which exhibits multi-mechanistic antimicrobial activity. Previously, increased antimicrobial activity against E. coli with nitric oxide releasing nanoparticles (NO-np) was demonstrated when combined with glutathione, versus NO-np alone, due to formation of S-nitrosoglutathione (GSNO), a potent transnitrosylating agent. To...

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ES0007060, and AFRL FA8650-05-1-5041. JDN acknowledges National Institutes of Health/National Institute of

ScholarsArchive@OSU

S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology

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