Background: Pre-genomic and post-genomic studies demonstrate that chlamydiae actively recombine in vitro and
in vivo, although the molecular and cellular biology of this process is not well understood. In this study, we
determined the genome sequence of twelve Chlamydia trachomatis recombinants that were generated in vitro
under antibiotic selection. These...
Successful host cell colonization by the Q fever pathogen, Coxiella burnetii, requires translocation of effector proteins into
the host cytosol by a Dot/Icm type 4B secretion system (T4BSS). In Legionella pneumophila, the two-component system (TCS)
PmrAB regulates the Dot/Icm T4BSS and several additional physiological processes associated with pathogenesis. Because PmrA...
Successful host cell colonization by the Q fever pathogen, Coxiella burnetii, requires translocation of effector proteins into
the host cytosol by a Dot/Icm type 4B secretion system (T4BSS). In Legionella pneumophila, the two-component system (TCS)
PmrAB regulates the Dot/Icm T4BSS and several additional physiological processes associated with pathogenesis. Because PmrA...
Successful host cell colonization by the Q fever pathogen, Coxiella burnetii, requires translocation of effector proteins into
the host cytosol by a Dot/Icm type 4B secretion system (T4BSS). In Legionella pneumophila, the two-component system (TCS)
PmrAB regulates the Dot/Icm T4BSS and several additional physiological processes associated with pathogenesis. Because PmrA...
Full Text:
Colonization of Mammalian Host Cells
Paul A. Beare,a KelsiM. Sandoz,a Charles L. Larson,a Dale Howe,a Brent
Successful host cell colonization by the Q fever pathogen, Coxiella burnetii, requires translocation of effector proteins into
the host cytosol by a Dot/Icm type 4B secretion system (T4BSS). In Legionella pneumophila, the two-component system (TCS)
PmrAB regulates the Dot/Icm T4BSS and several additional physiological processes associated with pathogenesis. Because PmrA...
Novel broad-spectrum antimicrobials are a critical component of a strategy for combating antibiotic-resistant pathogens. In this
study, we explored the activity of the broad-spectrum antiviral compound ST-669 for activity against different intracellular bacteria
and began a characterization of its mechanism of antimicrobial action. ST-669 inhibits the growth of three different...
The intracellular life cycle of Chlamydia has been difficult to study due to the inability to genetically manipulate the bacteria. As a result, indirect methods have been employed to study the pathogen and the aspects that contribute to its unique intracellular life cycle. A wide variety of laboratory adapted strains,...
Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We
have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a
research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course...
Full Text:
., Carson, S., Caruso, S. M., Clase, K., DeJong, R.
J., ... & Hatfull, G. F. (2014). A Broadly
Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We
have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a
research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course...
Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We
have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a
research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course...
