The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
The ability of flavoenzymes to reduce dioxygen varies greatly and is controlled by the protein environment that can cause either a rapid (oxidases) or sluggish (dehydrogenases) reaction. Previously, a “gatekeeper” amino acid residue was identified that controls the reactivity to dioxygen in proteins from the vanillyl alcohol oxidase superfamily of...
In the problem of testing the median using a random sample from a
certain distribution, and if no other parametric family is suggested,
the t-test is known to be the optimal procedure when this distribution
is normal. If the sample appears to be non-normal, one has the choice
either to...
The Laser Gravitational Wave Observatory, or LIGO, is built to observe gravitational waves as they propagate through space. Advanced LIGO is extremely sensitive
to movements of the test mass as small as 10⁻²¹ m/√Hz , which allows many signals other
than gravitational waves to be detected by the system. Pressure...
There were two viable theories of generation, preformation
and epigenesis, existing in the Seventeenth and
Eighteenth Centuries. Due to their irreconcilable nature,
they were often at loggerheads during this time interval.
The status of these generation theories can be effectively
understood in terms of Thomas Kuhn's conception of preparadigm
science....
Juvenile Chinook Salmon (Oncorhynchus tshawytscha) leave the natal reach at different times and move downstream at different rates which can increase their productivity by allowing them to utilize habitats on different temporal scales and spreading risk of localized stochastic events. This life history diversity can also allow fish to adapt...
The macroscopic description of the hysteretic behavior of two-phase flow in porous media remains a challenge. It is not obvious how to represent the underlying pore-scale processes at the Darcy-scale in a consistent way. Darcy-scale thermodynamic models do not completely eliminate hysteresis and our findings indicate that the shape of...