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Sustained time series have provided compelling evidence for progressive acidification of the
surface oceans through exchange with the growing atmospheric reservoir of carbon dioxide. However,
few long-term programs exist, and extrapolation of results from one site to larger oceanic expanses is
hampered by the lack of spatial coverage inherent to...
Sustained time series have provided compelling evidence for progressive acidification of the
surface oceans through exchange with the growing atmospheric reservoir of carbon dioxide. However,
few long-term programs exist, and extrapolation of results from one site to larger oceanic expanses is
hampered by the lack of spatial coverage inherent to...
Full Text:
., Church, M. J., Karl, D. M., Sadler, D. W., & Letelier, R. M. (2014).
Paired windward and leeward
BACKGROUND: The impact of cell-composition effects in analysis of DNA methylation data is now widely appreciated.
With the availability of a reference data set consisting of DNA methylation measurements on isolated cell types, it is
possible to impute cell proportions and adjust for them, but there is increasing interest in...
Full Text:
. Kelsey, John K. Wiencke, Carmen J. Marsit
Figure S1
Number of significant kΒ coefficients (q
BACKGROUND: The impact of cell-composition effects in analysis of DNA methylation data is now widely appreciated.
With the availability of a reference data set consisting of DNA methylation measurements on isolated cell types, it is
possible to impute cell proportions and adjust for them, but there is increasing interest in...
Full Text:
E Andres Houseman1*, Karl T Kelsey2, John K Wiencke3 and Carmen J Marsit4
Abstract
Background: The
BACKGROUND: Cell lineage-specific DNA methylation patterns distinguish normal human leukocyte subsets and can
be used to detect and quantify these subsets in peripheral blood. We have developed an approach that uses DNA
methylation to simultaneously quantify multiple leukocyte subsets, enabling investigation of immune modulations
in virtually any blood sample including...
BACKGROUND: Cell lineage-specific DNA methylation patterns distinguish normal human leukocyte subsets and can
be used to detect and quantify these subsets in peripheral blood. We have developed an approach that uses DNA
methylation to simultaneously quantify multiple leukocyte subsets, enabling investigation of immune modulations
in virtually any blood sample including...
Full Text:
, John K Wiencke2, E Andres Houseman3, Heather H Nelson4 and Karl T Kelsey1,5*
Abstract
Background: Cell