In three separate trials rats were fed either a basal diet deficient
in selenium and vitamin E or the same diet supplemented with
one or both of these factors. In addition to these treatments in two
of the trials, ethoxyquin was included to provide adequate lipid antioxidant
protection and to...
A series of four trials were conducted to determine the influence
of selenium supplementation of a selenium- and vitamin E-deficient
basal diet on the absorption, excretion, tissue distribution
and placental transfer of a single dose of tritium-labeled α-tocopherol
in the rat.
In the first trial, the effect of supplementation of...
The selenium-responsive syndromes and the discovery of
Factor 3-selenium focused attention on selenium in metabolism. Two
hypotheses have been advanced to explain the metabolic effect of
selenium: 1) substitution or sparing of alpha tocopherol, and 2) a
primary role in metabolism. The first hypothesis is supported by
Scott and Desai,...
One hundred and fifty-one weanling rats of both sexes were fed
control diets or diets containing 160 ppm diethylnitrosamine (DEN) or
150 ppm N-2-fluorenyl-acetamide (FAA). The carcinogen level was
calculated so that the LD₅₀ should be achieved at about 17 weeks.
Each carcinogen treatment was incorporated with three different diet...
Selenium deficiency in rats results in increased carbon metabolism,
approaching twice the rate of selenium supplemented animals
(normal). This is also reflected in a 50 percent increase in lysosomal
enzyme activity in tissues of selenium deficient animals.
Isolation of rat liver lysosomes shows a 17 percent increase in
membrane thickness...
The metabolism of pyrrolizidine alkaloids and other
drugs was studied with regard to nutritional status and
species differences. Pyrrolizidine alkaloids which are biotransformed
to severely toxic metabolites were isolated
from tansy ragwort (Senecio jacobaea). Semi-purified alkaloid
crystals containing five alkaloids (senecionine, seneciophylline,
jacobine, jacoline, and jacozine) were prepared
and found...
The testes of the gray-tailed vole (Microtus canicaudus Miller) exhibited a high affinity for selenium relative to other selected tissues. Uptake of selenium-75 in the testis-epididymis complex was delayed relative to uptake by the whole body, kidney, and liver. This pattern of uptake suggested that selenium was metabolically incorporated into...
The objective of our study was to investigate the effect of selenium on
selenoprotein W. Western blot analysis indicated that selenoprotein W is present in
muscle, brain, testis and spleen of rat tissues. Tissue distribution of selenoprotein W
was not altered in rats fed various selenium levels. Among muscle, brain,...
Bioavailability of selenium (Se) in processed tuna and
wheat products was studied in humans and rats. The protein
source of the rat diets was torula yeast with Se supplied by
either raw, precooked or canned tuna, or whole wheat flour,
bread or bran. Sodium selenite was used as a control....