Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...
We hypothesized that calpain activity is elevated in response to muscle damage. To test this hypothesis, we examined the degradation of α-fodrin into its 150 and 145 kDa fragments following either 20 eccentric or isometric contractions. In addition, experiments were performed in the presence or absence of E-64-d, a calpain...
I. Lithium alkyl and aryl monosubstituted cyclooctatetraenide
dianions (Li₂ C₈H₇-R; R = methyl, n- butyl, sec- butyl, tert- butyl,
phenyl and benzyl) were synthesized by the reaction of the appropriate
organolithium reagent with cyclooctatetraene in diethyl ether or
tetrahydrofuran. The reaction occurred cleanly and with good yield
of lithium monosubstituted...
The influence of natural enemies and plant apparency in
determining the abundance of the cabbage aphid Brevicoryne brassicae L.
and the imported cabbageworm Pieris rapae L. was examined on collards
grown in a collard monoculture and in a collard-alfalfa biculture.
This design was used to examine the factors affecting collardherbivore...
This paper investigates the atmospheric circulation and transport characteristics
of the Martian atmosphere (as modeled by a Mars GCM) for three sets of
conditions. The conditions are based on a combination of season and dust loading
(as parameterized by the optical depth, τ). The first experiment is for the Northern...
Despite its promise as a potentially beneficial new source of energy, the ocean-based renewable energy industry is still in its infancy, and like any new idea there are many unknowns with the potential to affect both people and our natural environments. A permit for marine renewable energy (MRE) must cut...