The thesis area is located in the Blue Mountains of northeast Oregon. Pre-Tertiary and Cenozoic rocks, divided on the basis of age and tectonic history, are exposed along the eroded crest of the Blue Mountain anticline. Permian (?) metasedimentary rocks probably correlate with the Elkhorn Ridge Argillite, and consist mainly...
Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...
Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver....
Perceived discrimination has been a topic that has been explored extensively in various different countries and regions (Awad 2010; Litchmore and Safdar 2015; Godley 2018; Dixon 2019). A growing concern for affected groups has prompted many of these studies, as perceived discrimination has been found to potentially negatively impact one's...