Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...
Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver....
The sinuous flight behavior of male Douglas-fir tussock
moths, Orgyia pseudotsugata, (McD.), is characterized by
positive anemotaxis and positive chemoklinotaxis and varies
depending on distance from the pheromone source, population
density, and time of day. Visual cues play a minor role
in close-range orientation to a pheromone source, but
males...
Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
In this study, pheromone and skin lipid samples collected from red-sided garter snakes (Thamnophis sirtalis parietalis) were exposed directly to either full-spectrum light or full-spectrum plus UVB light. In addition, female and male snakes were exposed to daily doses of either full-spectrum or full-spectrum and UVB light, after which the...
Major objectives of the study involved development of a laboratory
procedure to obtain mating, determining characteristics of female
sex attraction, and determination of the effects of temperature and
humidity on mating and fecundity. The second of two methods devised
to obtain mating, "the vertical airflow technique," was convenient to
employ...