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Filtering by: Committee Member Siddens, Lisbeth K.

Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

Creator:

Patel, Karan A.

Abstract:

Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....

Resource Type:

Honors College Thesis

Full Text:

Microsoft Word - K. Patel_Thesis_Body.docx Sulforaphane
Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:

You, Hyekyoung Hannah

Abstract:

Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...

Resource Type:

Honors College Thesis

Full Text:

, representing Environmental and Molecular Toxicology/Biochemistry and Biophysics Lisbeth K. Siddens