The discovery of novel compounds with antibacterial properties continues to be critically important.3 One potential source of such compounds is the cryptic genome of fungi known to produce biologically active molecules. A kmt6 mutant of the cereal pathogen Fusarium graminearum was previously developed through a histone H3 lysine 27 methyltransferase...
The Canada goose (Branta canadensis) monogastric gut is proposed to contain aerobic spore-forming bacteria that produce non-toxin substances that may promote anti-inflammatory immune responses. It is hypothesized that the aerobic bacteria found in samples of Canada goose microflora could have probiotic effects in other avian species or used for commercial...
As wolves return to their historic habitats both in Oregon and across the globe, emotions are running high between people either gladdened or disturbed by their homecoming. Prior to colonization, wolves occupied the entire Pacific Northwest alongside Indigenous peoples. However, European settlements that ultimately coalesced to form the state of...
Rates of benthic O₂ exchange are important measurements for determining organic matter remineralization, and can shed light on factors driving biogeochemical processes in coastal environments. Measurement of in situ O₂ consumption and production within permeable sediments, such as those found over ~43% of the Oregon-Washington shelf, has traditionally been done...
The lagoons spanning Alaska’s Beaufort Sea coast provide a unique habitat for arctic wildlife. These lagoons and the food webs they support face extreme seasonality with nine months of ice cover followed by a spring thaw that pulses a large amount of freshwater and nutrients into the lagoons. Bacteria link...
Community colleges are changing to meet the needs and demands of the 21st century and these changes are also a driving force behind the shifts that are happening to the essential functions of the presidents who lead the community colleges. In order to navigate the complex systems and lead colleges...
The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated
transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput
DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for
trimethylated histone H3 lysine 27 (H3K27me3), a...
Full Text:
Expression of Secondary Metabolite Gene Clusters
Lanelle R. Connolly., KristinaM. Smith., Michael Freitag
The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated
transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput
DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for
trimethylated histone H3 lysine 27 (H3K27me3), a...
The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for trimethylated histone H3 lysine 27 (H3K27me3), a...
PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...