It is well known that the mitochondrial genome has a much higher spontaneous mutation rate than the nuclear genome. mtDNA mutations have been identified in association with many diseases and aging. mtDNA replication continues throughout the cell cycle, even in post-mitotic cells. Therefore, a constant supply of nucleotides is required...
Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly
asymmetric, and this asymmetry probably contributes toward the elevated
mutation rate for the mitochondrial genome as compared with the nuclear
genome. To understand this asymmetry, we must identify pathways for synthesis
and accumulation of dNTPs within mitochondria. We have identified
ribonucleotide reductase...
This work presents a novel CCRW receiver that utilizes a window of variable width, for e˙ectively mitigating multipath and ambiguity in both civil and military positioning applica-tions using Global Navigation Satellite Systems (GNSS). This CCRW receiver incorporates a single stroboscopic window, whose width is iteratively reduced until the e˙ect of...
Deep neural networks currently comprise the backbone of many applications where safety is a critical concern, for example: autonomous driving and medical diagnostics. Unfortunately these systems currently fail to detect out-of-distribution (OOD) inputs and can be prone to making dangerous errors when exposed to them. In addition, these same systems...
The enzymes of dNTP synthesis in T4 infection associate to form a multienzyme complex, the T4 dNTP synthetase complex, facilitating the flow of metabolites en route to dNTPs, and their subsequent flow into DNA. Study of protein-protein interactions helps one to understand how the enzymes in the complex are organized...
With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...
In this thesis, maximum likelihood Doppler frequency estimation and phase noise suppression algorithms for Orthogonal Frequency Division Multiplexing (OFDM) systems are presented. A novel handover decision algorithm for wireless systems, called predictive base station switching (PBSS), is also introduced.
The maximum Doppler Frequency is the ratio of the speed of...