T cells are one of the key cells in the immune system. Although they are
not the first line of defense against a pathogen, their functions can greatly enhance
the phagocytosis and destruction of pathogens as well as the development of
antibody responses. Furthermore, even when responding T cells have...
The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized
for their immunosuppressive activity, which is mediated through an
intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR).
Laboratory animals exposed to TCDD are less resistant to infection and have severely
impaired humoral and cell-mediated immune responses. This dissertation addressed
the hypothesis that...
Although IL-4 is a well-characterized multi-functional cytokine, its role as a
survival factor in T cells is not completely understood. In an attempt to uncover
IL-4-mediated survival, we studied caspase activation in primary mouse T
lymphocytes undergoing death by neglect, activation-induced or steroid-induced
cell death. Here, we identify the executioner...
Proper immune function is indispensable, as failure to mount an immune
response against a pathogen can lead to serious complications or even death. T
cells act by enhancing the activation of phagocytic cells as well as the activation of
B cells. Their widespread influence on an immune response makes optimal...
The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...