Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Funding statement This work was supported by Fondo Clemente Estable-ANII (FCE_1_2011_1_7342), Institut Pasteur de Montevideo-FOCEM Mercosur (COF 03/11), NIH (NS058628) the Amyotrophic Lateral Sclerosis Association (00482), Department of Defense (AL140108), and by ECOS-SUD program (U14S02).

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

Creator:

Trias, Emiliano, Cassina, Patricia, Martínez-Palma, Laura, Moura, Ivan C., Beckman, Joseph S., Hermine, Olivier, Barbeito, Luis, Ibarburu, Sofía, Barreto-Núñez, Romina, Babdor, Joël, Maciel, Thiago T., Guillo, Matthias, Gros, Laurent, Dubreuil, Patrice, and Díaz-Amarilla, Pablo

Abstract:

Background: In the SOD1^G93A mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. Whether pharmacological downregulation of such aberrant glial cells will decrease motor neuron death and prolong...

Resource Type:

Article

Full Text:

), Institut Pasteur de Montevideo–FOCEM Mercosur (COF 03/11), NIH (NS058628) the Amyotrophic Lateral Sclerosis

ScholarsArchive@OSU

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

Limit your search

Creator

Date

Decade

Language

Peer Reviewed

Resource Type

Rights Statement

Search Constraints

Search Results

Limit your search