Index Catalog // ScholarsArchive@OSU

Toxicity Screening of Polycyclic Aromatic Hydrocarbons (PAHs) in Primary Human Bronchial Epithelial Cells

Creator:: Amador, Samantha B.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a known class of chemicals that are linked to a multitude of adverse health outcomes. There are over 1,500 of these chemicals across various families and subgroups. 16 of these PAHs, known as parent PAHs, are identified by the EPA for focused risk assessment within...
Resource Type:: Undergraduate Thesis

Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

Creator:: Patel, Karan A.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
Resource Type:: Honors College Thesis
Full Text:: Institute Susan C. Tilton, Committee Member, representing Environmental and Molecular Toxicology

Utilization of structure-activity-relationship for predicting chemical toxicity in primary human lung cells

Creator:: Galbreath, Amanda
Abstract:: There is a growing need to establish alternative approaches for assessing hazard from chemical exposure compared to the traditional method of animal testing. Approaches that relate chemical structure to biological activity are gaining acceptance in the field as in silico methods for characterizing and predicting chemical toxicity. In this study,...
Resource Type:: Undergraduate Thesis
Full Text:: Nam Kim, Paritosh Pande, Kim A. Anderson, Susan C. Tilton, and Robyn L. Tanguay. 2022. “A Comparative

Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

Creator:: Luker, George W.
Abstract:: There exists a growing need to establish a better in vitro model for evaluating PAH toxicity and carcinogenicity and to improve assessments of risk to human health, especially to the complex mixtures that exist in the environment. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants due to the incomplete combustion...
Resource Type:: Undergraduate Thesis
Full Text:: , Biotechnology August 23, 2018 2 APPROVED: Susan C. Tilton, Environmental and

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

Creator:: Holden, Laura, L.
Abstract:: Since 2007, electronic cigarette (e-cigarette) sales in the U.S. have surpassed those of tobacco cigarettes. This is due, in part, to manufacturer’s claims that they are a safer alternative to tobacco cigarettes. However, formaldehyde, acrolein, and diacetyl have been detected in e-cigarettes and public knowledge of e-cigarette composition and potential...
Resource Type:: Masters Thesis
Full Text:: ). Thermal decomposition of cinnamic acid at 300°C in the presence of oxygen leads to the formation of

On edge disjoint Hamiltonian cycles in torus and Gaussian networks

Creator:: Alazemi, Fawaz M.
Abstract:: Many algorithms in parallel systems can be easily solved if we can generate a Hamiltonian cycle on the underly network. Finding Hamiltonian cycle is a well known NP-complete problem. For specific instances of regular graphs, such as Torus and Gaussian network, one can easily find Hamiltonian cycles. In this thesis,...
Resource Type:: Masters Thesis
Full Text:: Gaussian network G bn/2c α , for 1 ≤ 2r ≤ n < 2r+1. c©Copyright by Fawaz M. Alazemi December 4, 2014

Brassicas, microbes, and metabolites : a multi-omic investigation of cruciferous vegetable phytochemical metabolism

Creator:: Bouranis, John A.
Abstract:: Phytochemicals from cruciferous vegetables, such as broccoli, contain a multitude of bioactive compounds that prevent and suppress cancer and promote optimal health. Some of the health promoting effects of cruciferous vegetables are attributed to a class of compounds known as isothiocyanates (ITCs), a potent nuclear factor erythroid 2–related factor 2...
Resource Type:: Dissertation
Full Text:: members Dr. Norm Hord, Dr. Maret Traber, Dr. Susan Tilton, and Dr. Fred Stevens – thank you for your

Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

Creator:: Wilson, Lindsay B.
Abstract:: The field of toxicology is challenged with a vast number of environmental chemicals and mixtures to which humans and ecosystems are exposed with limited toxicity data available. Chemical hazard assessment traditionally utilizes mammalian models and can be both cost- and time-limiting and may pose ethical concerns. To rapidly tackle this...
Resource Type:: Dissertation
Full Text:: – Mary Mucia, Cheyenne Pozar, Drs. Susan Tilton, Kim Anderson, Diana Rohlman, Molly Kile, Craig Marcus

Elucidating Structure-bioactivity Relationships and Modes of Action of Per- and Polyfluoroalkyl Substance Toxicity in Zebrafish

Creator:: Rericha, Yvonne
Abstract:: Per- and polyfluoroalkyl substances (PFAS) are a broad class of anthropogenic chemicals characterized by highly stable carbon-fluorine (C-F) bonds. PFAS are widely used in industrial and consumer products for their surface-active and stain-resistant properties and are ubiquitously detected in environmental media, biota, and human biomatrices. Although some PFAS are known...
Resource Type:: Dissertation
Full Text:: Field, Dr. Susan Tilton, Dr. Marilyn Mackiewicz, and Dr. Diana Rohlman. My close collaborations with

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Creator:: Shankar, Prarthana
Abstract:: All animals have developed the critical ability to detect, respond to, and detoxify a large array of environmental chemicals and stressors that can cause adverse health effects. Important examples of landmark contaminants around the world are polycyclic aromatic hydrocarbons (PAHs) and dioxins, both of which can act via the aryl...
Resource Type:: Dissertation
Full Text:: . Thomas Sharpton, Dr. Susan Tilton, and Dr. Jaga Giebultowicz, and Dr. Kate Shilke for their critical

ScholarsArchive@OSU

Toxicity Screening of Polycyclic Aromatic Hydrocarbons (PAHs) in Primary Human Bronchial Epithelial Cells

Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

Utilization of structure-activity-relationship for predicting chemical toxicity in primary human lung cells

Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

On edge disjoint Hamiltonian cycles in torus and Gaussian networks

Brassicas, microbes, and metabolites : a multi-omic investigation of cruciferous vegetable phytochemical metabolism

Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

Elucidating Structure-bioactivity Relationships and Modes of Action of Per- and Polyfluoroalkyl Substance Toxicity in Zebrafish

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

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